Inflammatory effects of peritoneal dialysis: Evidence of systemic monocyte activation

Carmelo Libetta, Luca De Nicola, Teresa Rampino, Walter De Simone, Bruno Memoli

Research output: Contribution to journalArticlepeer-review

Abstract

We evaluated in peritonitis-free patients undergoing continuous ambulatory peritoneal dialysis (CAPD) the release of both interleukin-6 (IL-6) and β-2-microglobulin (β2m) by cultured peripheral blood mononuclear cells (PBMC), as well as the levels of serum amyloid A (SAA), that is, the main hepatic acute phase protein during inflammation. The same measurements were obtained in hemodialysis (HD) patients, uremic non-dialyzed patients (ESRD) and healthy controls (CON). In CAPD, IL-6 production from PBMC was markedly increased in comparison to the control value (600.7 ± 104.3 vs. 14.2 ± 3.6 pg x 106 PBMC/24 hr, P <0.005). Similarly, a striking enhancement of the PBMC release of β2m was detected in CAPD with respect to CON (10.1 ± 2.6 vs. 0.063 ± 0.013 μg/3 x 106 PBMC/24 hr, P <0.001). Also, the SAA levels were significantly greater in CAPD patients (21.3 ± 8.7 μg/dl) than in controls (3.14 ± 0.17 μg/dl, P <0.05). Analogous increases of both IL-6 and β2m cell releases, as well as of SAA levels, were observed in HD patients. No difference concerning the three parameters was detected between CON and ESRD. In conclusion, CAPD induces per se PBMC activation with an enhanced release of both IL-6 and β2m; this is associated to higher levels of SAA. These systemic inflammatory effects are comparable to those observed in HD patients indicating that CAPD is similar to HD in terms of biocompatibility of the treatment.

Original languageEnglish
Pages (from-to)506-511
Number of pages6
JournalKidney International
Volume49
Issue number2
Publication statusPublished - 1996

ASJC Scopus subject areas

  • Nephrology

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