Inflammatory Markers and Genetic Polymorphisms in Workers Exposed to Flour Dust

Paolo Marraccini; Laura Cantone; Francesco Barretta; Chiara Marsili; Paolo Leghissa; Marisa Santini; Francesca Elli; Pier A. Bertazzi; Mario Previdi

doi:10.1097/JOM.0000000000000706

Inflammatory Markers and Genetic Polymorphisms in Workers Exposed to Flour Dust

Paolo Marraccini, Laura Cantone, Francesco Barretta, Chiara Marsili, Paolo Leghissa, Marisa Santini, Francesca Elli, Pier A. Bertazzi, Mario Previdi

Fondazione IRCCS Ca' Granda- Ospedale Maggiore Policlinico

Research output: Contribution to journal › Article › peer-review

Abstract

OBJECTIVE:: The aim of this study is to evaluate inflammatory markers and pro-inflammatory CD14 and Toll-like Receptor 4 (TLR4) polymorphisms in workers exposed to flour dust. METHODS:: Polymorphisms in TLR4 and CD14 were identified in our study population of 167 workers that included 63 healthy subjects (HS), 45 atopic subjects (A), and 59 subjects diagnosed clinically with occupational asthma/rhinitis (OAR). Endpoint measures in this study included fractional exhaled nitric oxide and serum concentrations of interleukin IL-6, IL-8, and tumor necrosis factor-alpha (TNF-α). RESULTS:: We identified a polymorphism in CD14 (rs2569190) that may be differentially expressed (P?=?0.06). IL-6 concentrations in the serum were significantly higher in the A and OAR groups (P?

Original language	English
Pages (from-to)	e166-e170
Number of pages	5
Journal	Journal of Occupational and Environmental Medicine
Volume	58
Issue number	5
DOIs	https://doi.org/10.1097/JOM.0000000000000706
Publication status	Published - 2016

ASJC Scopus subject areas

Public Health, Environmental and Occupational Health

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Inflammatory Markers and Genetic Polymorphisms in Workers Exposed to Flour Dust. / Marraccini, Paolo; Cantone, Laura; Barretta, Francesco; Marsili, Chiara; Leghissa, Paolo; Santini, Marisa; Elli, Francesca; Bertazzi, Pier A.; Previdi, Mario.

In: Journal of Occupational and Environmental Medicine, Vol. 58, No. 5, 2016, p. e166-e170.

Research output: Contribution to journal › Article › peer-review

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abstract = "OBJECTIVE:: The aim of this study is to evaluate inflammatory markers and pro-inflammatory CD14 and Toll-like Receptor 4 (TLR4) polymorphisms in workers exposed to flour dust. METHODS:: Polymorphisms in TLR4 and CD14 were identified in our study population of 167 workers that included 63 healthy subjects (HS), 45 atopic subjects (A), and 59 subjects diagnosed clinically with occupational asthma/rhinitis (OAR). Endpoint measures in this study included fractional exhaled nitric oxide and serum concentrations of interleukin IL-6, IL-8, and tumor necrosis factor-alpha (TNF-α). RESULTS:: We identified a polymorphism in CD14 (rs2569190) that may be differentially expressed (P?=?0.06). IL-6 concentrations in the serum were significantly higher in the A and OAR groups (P?",

author = "Paolo Marraccini and Laura Cantone and Francesco Barretta and Chiara Marsili and Paolo Leghissa and Marisa Santini and Francesca Elli and Bertazzi, {Pier A.} and Mario Previdi",

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AU - Marraccini, Paolo

AU - Cantone, Laura

AU - Barretta, Francesco

AU - Marsili, Chiara

AU - Leghissa, Paolo

AU - Santini, Marisa

AU - Elli, Francesca

AU - Bertazzi, Pier A.

AU - Previdi, Mario

PY - 2016

Y1 - 2016

N2 - OBJECTIVE:: The aim of this study is to evaluate inflammatory markers and pro-inflammatory CD14 and Toll-like Receptor 4 (TLR4) polymorphisms in workers exposed to flour dust. METHODS:: Polymorphisms in TLR4 and CD14 were identified in our study population of 167 workers that included 63 healthy subjects (HS), 45 atopic subjects (A), and 59 subjects diagnosed clinically with occupational asthma/rhinitis (OAR). Endpoint measures in this study included fractional exhaled nitric oxide and serum concentrations of interleukin IL-6, IL-8, and tumor necrosis factor-alpha (TNF-α). RESULTS:: We identified a polymorphism in CD14 (rs2569190) that may be differentially expressed (P?=?0.06). IL-6 concentrations in the serum were significantly higher in the A and OAR groups (P?

AB - OBJECTIVE:: The aim of this study is to evaluate inflammatory markers and pro-inflammatory CD14 and Toll-like Receptor 4 (TLR4) polymorphisms in workers exposed to flour dust. METHODS:: Polymorphisms in TLR4 and CD14 were identified in our study population of 167 workers that included 63 healthy subjects (HS), 45 atopic subjects (A), and 59 subjects diagnosed clinically with occupational asthma/rhinitis (OAR). Endpoint measures in this study included fractional exhaled nitric oxide and serum concentrations of interleukin IL-6, IL-8, and tumor necrosis factor-alpha (TNF-α). RESULTS:: We identified a polymorphism in CD14 (rs2569190) that may be differentially expressed (P?=?0.06). IL-6 concentrations in the serum were significantly higher in the A and OAR groups (P?

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Inflammatory Markers and Genetic Polymorphisms in Workers Exposed to Flour Dust

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