TY - JOUR
T1 - Inflammatory Markers and Genetic Polymorphisms in Workers Exposed to Flour Dust
AU - Marraccini, Paolo
AU - Cantone, Laura
AU - Barretta, Francesco
AU - Marsili, Chiara
AU - Leghissa, Paolo
AU - Santini, Marisa
AU - Elli, Francesca
AU - Bertazzi, Pier A.
AU - Previdi, Mario
PY - 2016
Y1 - 2016
N2 - OBJECTIVE:: The aim of this study is to evaluate inflammatory markers and pro-inflammatory CD14 and Toll-like Receptor 4 (TLR4) polymorphisms in workers exposed to flour dust. METHODS:: Polymorphisms in TLR4 and CD14 were identified in our study population of 167 workers that included 63 healthy subjects (HS), 45 atopic subjects (A), and 59 subjects diagnosed clinically with occupational asthma/rhinitis (OAR). Endpoint measures in this study included fractional exhaled nitric oxide and serum concentrations of interleukin IL-6, IL-8, and tumor necrosis factor-alpha (TNF-α). RESULTS:: We identified a polymorphism in CD14 (rs2569190) that may be differentially expressed (P?=?0.06). IL-6 concentrations in the serum were significantly higher in the A and OAR groups (P?
AB - OBJECTIVE:: The aim of this study is to evaluate inflammatory markers and pro-inflammatory CD14 and Toll-like Receptor 4 (TLR4) polymorphisms in workers exposed to flour dust. METHODS:: Polymorphisms in TLR4 and CD14 were identified in our study population of 167 workers that included 63 healthy subjects (HS), 45 atopic subjects (A), and 59 subjects diagnosed clinically with occupational asthma/rhinitis (OAR). Endpoint measures in this study included fractional exhaled nitric oxide and serum concentrations of interleukin IL-6, IL-8, and tumor necrosis factor-alpha (TNF-α). RESULTS:: We identified a polymorphism in CD14 (rs2569190) that may be differentially expressed (P?=?0.06). IL-6 concentrations in the serum were significantly higher in the A and OAR groups (P?
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U2 - 10.1097/JOM.0000000000000706
DO - 10.1097/JOM.0000000000000706
M3 - Article
AN - SCOPUS:84962114178
VL - 58
SP - e166-e170
JO - Journal of Occupational and Environmental Medicine
JF - Journal of Occupational and Environmental Medicine
SN - 1076-2752
IS - 5
ER -