Inflammatory Markers and Genetic Polymorphisms in Workers Exposed to Flour Dust

Paolo Marraccini, Laura Cantone, Francesco Barretta, Chiara Marsili, Paolo Leghissa, Marisa Santini, Francesca Elli, Pier A. Bertazzi, Mario Previdi

Research output: Contribution to journalArticlepeer-review

Abstract

OBJECTIVE:: The aim of this study is to evaluate inflammatory markers and pro-inflammatory CD14 and Toll-like Receptor 4 (TLR4) polymorphisms in workers exposed to flour dust. METHODS:: Polymorphisms in TLR4 and CD14 were identified in our study population of 167 workers that included 63 healthy subjects (HS), 45 atopic subjects (A), and 59 subjects diagnosed clinically with occupational asthma/rhinitis (OAR). Endpoint measures in this study included fractional exhaled nitric oxide and serum concentrations of interleukin IL-6, IL-8, and tumor necrosis factor-alpha (TNF-α). RESULTS:: We identified a polymorphism in CD14 (rs2569190) that may be differentially expressed (P?=?0.06). IL-6 concentrations in the serum were significantly higher in the A and OAR groups (P?

Original languageEnglish
Pages (from-to)e166-e170
Number of pages5
JournalJournal of Occupational and Environmental Medicine
Volume58
Issue number5
DOIs
Publication statusPublished - 2016

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health

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