OBJECTIVE:: The aim of this study is to evaluate inflammatory markers and pro-inflammatory CD14 and Toll-like Receptor 4 (TLR4) polymorphisms in workers exposed to flour dust. METHODS:: Polymorphisms in TLR4 and CD14 were identified in our study population of 167 workers that included 63 healthy subjects (HS), 45 atopic subjects (A), and 59 subjects diagnosed clinically with occupational asthma/rhinitis (OAR). Endpoint measures in this study included fractional exhaled nitric oxide and serum concentrations of interleukin IL-6, IL-8, and tumor necrosis factor-alpha (TNF-α). RESULTS:: We identified a polymorphism in CD14 (rs2569190) that may be differentially expressed (P?=?0.06). IL-6 concentrations in the serum were significantly higher in the A and OAR groups (P?
|Number of pages||5|
|Journal||Journal of Occupational and Environmental Medicine|
|Publication status||Published - 2016|
ASJC Scopus subject areas
- Public Health, Environmental and Occupational Health