TY - JOUR
T1 - Inflammatory molecules
T2 - A target for treatment of systemic autoimmune diseases
AU - Tincani, A.
AU - Andreoli, L.
AU - Bazzani, C.
AU - Bosiso, D.
AU - Sozzani, S.
PY - 2007/11
Y1 - 2007/11
N2 - Inflammation is a process to protect the host against infection and danger signals. However, many pathologic conditions, including autoimmune diseases, are sustained by perpetual activation of the inflammatory process. In the past few years our knowledge about the molecular basis of inflammation have been uncovered and now much is known about the primary role of pro-inflammatory cytokines such as IL-1 and TNF. In the early '90s, anti-cytokine therapies started and confirmed the primary role of TNF in autoimmune diseases, such as rheumatoid arthritis, Crohn's Disease and psoriasis. Increasing understanding of the role of inflammatory mediators in inflammation and diseases is opening new avenues for the treatment of inflammatory-based diseases through selective targeting of cytokines and lipid mediators.
AB - Inflammation is a process to protect the host against infection and danger signals. However, many pathologic conditions, including autoimmune diseases, are sustained by perpetual activation of the inflammatory process. In the past few years our knowledge about the molecular basis of inflammation have been uncovered and now much is known about the primary role of pro-inflammatory cytokines such as IL-1 and TNF. In the early '90s, anti-cytokine therapies started and confirmed the primary role of TNF in autoimmune diseases, such as rheumatoid arthritis, Crohn's Disease and psoriasis. Increasing understanding of the role of inflammatory mediators in inflammation and diseases is opening new avenues for the treatment of inflammatory-based diseases through selective targeting of cytokines and lipid mediators.
KW - Biological therapies
KW - Chemokines
KW - Inflammation
KW - Rheumatoid Arthritis
KW - Systemic Lupus Erythematosus
UR - http://www.scopus.com/inward/record.url?scp=35448943946&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=35448943946&partnerID=8YFLogxK
U2 - 10.1016/j.autrev.2007.03.001
DO - 10.1016/j.autrev.2007.03.001
M3 - Article
C2 - 17967717
AN - SCOPUS:35448943946
VL - 7
SP - 1
EP - 7
JO - Autoimmunity Reviews
JF - Autoimmunity Reviews
SN - 1568-9972
IS - 1
ER -