TY - JOUR
T1 - Inflammatory molecules in Frontotemporal Dementia
T2 - Cerebrospinal fluid signature of progranulin mutation carriers
AU - Galimberti, D.
AU - Bonsi, R.
AU - Fenoglio, C.
AU - Serpente, M.
AU - Cioffi, S. M G
AU - Fumagalli, G.
AU - Arighi, A.
AU - Ghezzi, L.
AU - Arcaro, M.
AU - Mercurio, M.
AU - Rotondo, E.
AU - Scarpini, E.
PY - 2015/10/1
Y1 - 2015/10/1
N2 - Mutations in progranulin gene (. GRN) are one of the major causes of autosomal dominant Frontotemporal Lobar Degeneration (FTLD). Progranulin displays anti-inflammatory properties and is likely a ligand of Tumor Necrosis Factor (TNF) receptor 2, expressed on microglia. A few cytokines and chemokines are altered in cerebrospinal fluid (CSF) from patients with sporadic FTLD, whereas no information is available in familial cases. We evaluated, through BioPlex, levels of 27 inflammatory molecules, including cytokines, chemokines, and related receptors, in CSF and matched serum, from FTLD patients carrying GRN mutations as compared with sporadic FTLD with no GRN mutations and controls. Mean. ±. SD Monocyte Chemoattractant Protein-1 (MCP-1) levels were significantly increased in CSF from sporadic FTLD patients as compared with controls (334.27±151.5 versus 159.7±49. pg/ml; P≤0.05). In GRN mutation carriers versus controls, CSF levels of MCP-1 were unchanged, whereas Interferon-γ-inducible protein-10 (IP-10) levels were increased (809.17. ±240.0 versus 436.61±202.5. pg/ml; P=0.012). In the same group, TNFα and Interleukin (IL)-15 levels were decreased (3.18. ±1.41 versus 35.68±30.5pg/ml; P=0.013 and 9.34±5.54 versus 19.15±10.03pg/ml; P= 0.023, respectively). Conversely, Regulated upon Activation, Normal T-cell Expressed, and Secreted (RANTES) levels were decreased in patients, with or without mutations, as compared with controls (4.63±3.30 and 2.58±20 versus 87.57±70. pg/ml, respectively; P
AB - Mutations in progranulin gene (. GRN) are one of the major causes of autosomal dominant Frontotemporal Lobar Degeneration (FTLD). Progranulin displays anti-inflammatory properties and is likely a ligand of Tumor Necrosis Factor (TNF) receptor 2, expressed on microglia. A few cytokines and chemokines are altered in cerebrospinal fluid (CSF) from patients with sporadic FTLD, whereas no information is available in familial cases. We evaluated, through BioPlex, levels of 27 inflammatory molecules, including cytokines, chemokines, and related receptors, in CSF and matched serum, from FTLD patients carrying GRN mutations as compared with sporadic FTLD with no GRN mutations and controls. Mean. ±. SD Monocyte Chemoattractant Protein-1 (MCP-1) levels were significantly increased in CSF from sporadic FTLD patients as compared with controls (334.27±151.5 versus 159.7±49. pg/ml; P≤0.05). In GRN mutation carriers versus controls, CSF levels of MCP-1 were unchanged, whereas Interferon-γ-inducible protein-10 (IP-10) levels were increased (809.17. ±240.0 versus 436.61±202.5. pg/ml; P=0.012). In the same group, TNFα and Interleukin (IL)-15 levels were decreased (3.18. ±1.41 versus 35.68±30.5pg/ml; P=0.013 and 9.34±5.54 versus 19.15±10.03pg/ml; P= 0.023, respectively). Conversely, Regulated upon Activation, Normal T-cell Expressed, and Secreted (RANTES) levels were decreased in patients, with or without mutations, as compared with controls (4.63±3.30 and 2.58±20 versus 87.57±70. pg/ml, respectively; P
KW - Cerebrospinal fluid
KW - Chemokines
KW - Cytokines
KW - Frontotemporal Dementia (FTD)
KW - Frontotemporal Lobar Degeneration (FTLD)
KW - Inflammation
KW - Pick dementia
KW - Progranulin (GRN)
UR - http://www.scopus.com/inward/record.url?scp=84940591561&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84940591561&partnerID=8YFLogxK
U2 - 10.1016/j.bbi.2015.05.006
DO - 10.1016/j.bbi.2015.05.006
M3 - Article
C2 - 26021560
AN - SCOPUS:84940591561
VL - 49
SP - 182
EP - 187
JO - Brain, Behavior, and Immunity
JF - Brain, Behavior, and Immunity
SN - 0889-1591
ER -