Inflammatory pathways of seizure disorders

Nicola Marchi, Tiziana Granata, Damir Janigro

Research output: Contribution to journalArticlepeer-review


Epilepsy refers to a cluster of neurological diseases characterized by seizures. Although many forms of epilepsy have a well-defined immune etiology, in other forms of epilepsy an altered immune response is only suspected. In general, the hypothesis that inflammation contributes to seizures is supported by experimental results. Additionally, antiepileptic maneuvers may act as immunomodulators and anti-inflammatory therapies can treat seizures. Triggers of seizure include a bidirectional communication between the nervous system and organs of immunity. Thus, a crucial cellular interface protecting from immunological seizures is the blood-brain barrier (BBB). Here, we summarize recent advances in the understanding and treatment of epileptic seizures that derive from a non-neurocentric viewpoint and suggest key avenues for future research.

Original languageEnglish
Pages (from-to)55-65
Number of pages11
JournalTrends in Neurosciences
Issue number2
Publication statusPublished - Feb 2014


  • Antiepileptic drugs
  • Blood-brain barrier
  • Corticosteroids
  • Immunomodulatory axis
  • Infection
  • Inflammation
  • Vagus nerve stimulation

ASJC Scopus subject areas

  • Neuroscience(all)


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