Inflammatory polyarthropathy and bone remodeling in HTLV-I tax- transgenic mice

D. Saggioro, A. Rosato, G. Esposito, M. P. Rosenberg, J. Harrison, B. K. Felber, G. N. Pavlakis, L. Chieco-Bianchi

Research output: Contribution to journalArticlepeer-review

Abstract

Transgenic mice carrying the tax gene of human T-cell lymphotropic virus type I displayed a high prevalence of arthropathy. The percentage of affected animals increased with age, reaching a peak of 43% at 20 months. Southern analysis of deoxyribonucleic acid (DNA) from tissue samples indicated that disease development was related to tax copy number. Histopathologic evaluation of the ankle joints disclosed deep erosion of the synovial lining, fibrous tissue proliferation together with angiogenesis, mononuclear cell infiltration, and activation of osteoclasts. Radiologic examination confirmed joint involvement and revealed bone architecture modifications. The phenotype exhibited by the affected animals closely resembles that of seronegative arthritis in humans, and may indicate tax protein as a causal agent of arthropathy observed in HTLV-I infected individuals.

Original languageEnglish
Pages (from-to)272-280
Number of pages9
JournalJournal of Acquired Immune Deficiency Syndromes and Human Retrovirology
Volume14
Issue number3
Publication statusPublished - 1997

Keywords

  • Arthropathy
  • Bone remodeling
  • Tax protein

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Virology

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