Inflammatory potential of diet and risk of lymphoma in the European Prospective Investigation into Cancer and Nutrition. European journal of nutrition

Marta Solans, Yolanda Benavente, Marc Saez, Antonio Agudo, Paula Jakszyn, Sabine Naudin, Fatemeh Saberi Hosnijeh, Marc Gunter, Inge Huybrechts, Pietro Ferrari, Caroline Besson, Yahya Mahamat-Saleh, Marie-Christine Boutron-Ruault, Tilman Kühn, Rudolf Kaaks, Heiner Boeing, Cristina Lasheras, Maria-Jose Sánchez, Pilar Amiano, María Dolores ChirlaqueEva Ardanaz, Julie A. Schmidt, Paolo Vineis, Elio Riboli, Antonia Trichopoulou, Anna Karakatsani, Elisavet Valanou, Giovanna Masala, Claudia Agnoli, Rosario Tumino, Carlotta Sacerdote, Amalia Mattiello, Guri Skeie, Elisabete Weiderpass, Mats Jerkeman, Joana Alves Dias, Florentin Späth, Lena Maria Nilsson, Christina C. Dahm, Kim Overvad, Kristina Elin Nielsen Petersen, Anne Tjønneland, Silvia de Sanjose, Roel Vermeulen, Alexandra Nieters, Delphine Casabonne

Research output: Contribution to journalArticlepeer-review

Abstract

INTRODUCTION: Chronic inflammation plays a critical role in lymphomagenesis and several dietary factors seem to be involved its regulation. The aim of the current study was to assess the association between the inflammatory potential of the diet and the risk of lymphoma and its subtypes in the European Investigation into Cancer and Nutrition (EPIC) study. METHODS: The analysis included 476,160 subjects with an average follow-up of 13.9 years, during which 3,136 lymphomas (135 Hodgkin lymphoma (HL), 2606 non-Hodgkin lymphoma (NHL) and 395 NOS) were identified. The dietary inflammatory potential was assessed by means of an inflammatory score of the diet (ISD), calculated using 28 dietary components and their corresponding inflammatory weights. The association between the ISD and lymphoma risk was estimated by hazard ratios (HR) and 95% confidence intervals (CI) calculated by multivariable Cox regression models adjusted for potential confounders. RESULTS: The ISD was not associated with overall lymphoma risk. Among lymphoma subtypes, a positive association between the ISD and mature B-cell NHL (HR for a 1-SD increase: 1.07 (95% CI 1.01; 1.14), p trend = 0.03) was observed. No statistically significant association was found among other subtypes. However, albeit with smaller number of cases, a suggestive association was observed for HL (HR for a 1-SD increase = 1.22 (95% CI 0.94; 1.57), p trend 0.13). CONCLUSIONS: Our findings suggested that a high ISD score, reflecting a pro-inflammatory diet, was modestly positively associated with the risk of B-cell lymphoma subtypes. Further large prospective studies on low-grade inflammation induced by diet are warranted to confirm these findings.
Original languageEnglish
Pages (from-to)813-823
Number of pages11
JournalEuropean Journal of Nutrition
Volume59
Issue number2
DOIs
Publication statusPublished - 2020

Keywords

  • Adult
  • Europe
  • Female
  • Humans
  • Male
  • Middle Aged
  • Prospective Studies
  • Risk Factors
  • Aged
  • Lymphoma
  • Cohort Studies
  • Nutrition
  • Chronic inflammation
  • Inflammatory score of the diet
  • Prospective studies
  • *Nutritional Status
  • Causality
  • Diet/*adverse effects
  • Inflammation/*pathology
  • Lymphoma/*epidemiology/*pathology

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