Inflammatory potential of the diet and risk of gastric cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) study

Antonio Agudo, Valerie Cayssials, Catalina Bonet, Anne Tjønneland, Kim Overvad, Marie-Christine Boutron-Ruault, Aurélie Affret, Guy Fagherazzi, Verena Katzke, Ruth Schübel, Antonia Trichopoulou, Anna Karakatsani, Carlo La Vecchia, Domenico Palli, Sara Grioni, Rosario Tumino, Fulvio Ricceri, Salvatore Panico, Bas Bueno-de-Mesquita, Petra H Peeters & 20 others Elisabete Weiderpass, Guri Skeie, Theresa H Nøst, Cristina Lasheras, Miguel Rodríguez-Barranco, Pilar Amiano, María-Dolores Chirlaque, Eva Ardanaz, Bodil Ohlsson, Joana A Dias, Lena M Nilsson, Robin Myte, Kay-Tee Khaw, Aurora Perez-Cornago, Marc Gunter, Inge Huybrechts, Amanda J Cross, Kostas Tsilidis, Elio Riboli, Paula Jakszyn

Research output: Contribution to journalArticle

Abstract

Background: Chronic inflammation plays a critical role in the pathogenesis of the 2 major types of gastric cancer. Several foods, nutrients, and nonnutrient food components seem to be involved in the regulation of chronic inflammation.

Objective: We assessed the association between the inflammatory potential of the diet and the risk of gastric carcinoma, overall and for the 2 major subsites: cardia cancers and noncardia cancers.

Design: A total of 476,160 subjects (30% men, 70% women) from the European Investigation into Cancer and Nutrition (EPIC) study were followed for 14 y, during which 913 incident cases of gastric carcinoma were identified, including 236 located in the cardia, 341 in the distal part of the stomach (noncardia), and 336 with overlapping or unknown tumor site. The dietary inflammatory potential was assessed by means of an inflammatory score of the diet (ISD), calculated with the use of 28 dietary components and their corresponding inflammatory scores. The association between the ISD and gastric cancer risk was estimated by HRs and 95% CIs calculated by multivariate Cox regression models adjusted for confounders.

Results: The inflammatory potential of the diet was associated with an increased risk of gastric cancer. The HR (95% CI) for each increase in 1 SD of the ISD were 1.25 (1.12, 1.39) for all gastric cancers, 1.30 (1.06, 1.59) for cardia cancers, and 1.07 (0.89, 1.28) for noncardia cancers. The corresponding values for the highest compared with the lowest quartiles of the ISD were 1.66 (1.26, 2.20), 1.94 (1.14, 3.30), and 1.07 (0.70, 1.70), respectively.

Conclusions: Our results suggest that low-grade chronic inflammation induced by the diet may be associated with gastric cancer risk. This pattern seems to be more consistent for gastric carcinomas located in the cardia than for those located in the distal stomach. This study is listed on the ISRCTN registry as ISRCTN12136108.

Original languageEnglish
Pages (from-to)607-616
Number of pages10
JournalAmerican Journal of Clinical Nutrition
Volume107
Issue number4
DOIs
Publication statusPublished - Apr 1 2018

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Stomach Neoplasms
Cardia
Diet
Stomach
Neoplasms
Inflammation
Carcinoma
Food
Proportional Hazards Models
Registries

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Inflammatory potential of the diet and risk of gastric cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. / Agudo, Antonio; Cayssials, Valerie; Bonet, Catalina; Tjønneland, Anne; Overvad, Kim; Boutron-Ruault, Marie-Christine; Affret, Aurélie; Fagherazzi, Guy; Katzke, Verena; Schübel, Ruth; Trichopoulou, Antonia; Karakatsani, Anna; La Vecchia, Carlo; Palli, Domenico; Grioni, Sara; Tumino, Rosario; Ricceri, Fulvio; Panico, Salvatore; Bueno-de-Mesquita, Bas; Peeters, Petra H; Weiderpass, Elisabete; Skeie, Guri; Nøst, Theresa H; Lasheras, Cristina; Rodríguez-Barranco, Miguel; Amiano, Pilar; Chirlaque, María-Dolores; Ardanaz, Eva; Ohlsson, Bodil; Dias, Joana A; Nilsson, Lena M; Myte, Robin; Khaw, Kay-Tee; Perez-Cornago, Aurora; Gunter, Marc; Huybrechts, Inge; Cross, Amanda J; Tsilidis, Kostas; Riboli, Elio; Jakszyn, Paula.

In: American Journal of Clinical Nutrition, Vol. 107, No. 4, 01.04.2018, p. 607-616.

Research output: Contribution to journalArticle

Agudo, A, Cayssials, V, Bonet, C, Tjønneland, A, Overvad, K, Boutron-Ruault, M-C, Affret, A, Fagherazzi, G, Katzke, V, Schübel, R, Trichopoulou, A, Karakatsani, A, La Vecchia, C, Palli, D, Grioni, S, Tumino, R, Ricceri, F, Panico, S, Bueno-de-Mesquita, B, Peeters, PH, Weiderpass, E, Skeie, G, Nøst, TH, Lasheras, C, Rodríguez-Barranco, M, Amiano, P, Chirlaque, M-D, Ardanaz, E, Ohlsson, B, Dias, JA, Nilsson, LM, Myte, R, Khaw, K-T, Perez-Cornago, A, Gunter, M, Huybrechts, I, Cross, AJ, Tsilidis, K, Riboli, E & Jakszyn, P 2018, 'Inflammatory potential of the diet and risk of gastric cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) study', American Journal of Clinical Nutrition, vol. 107, no. 4, pp. 607-616. https://doi.org/10.1093/ajcn/nqy002
Agudo, Antonio ; Cayssials, Valerie ; Bonet, Catalina ; Tjønneland, Anne ; Overvad, Kim ; Boutron-Ruault, Marie-Christine ; Affret, Aurélie ; Fagherazzi, Guy ; Katzke, Verena ; Schübel, Ruth ; Trichopoulou, Antonia ; Karakatsani, Anna ; La Vecchia, Carlo ; Palli, Domenico ; Grioni, Sara ; Tumino, Rosario ; Ricceri, Fulvio ; Panico, Salvatore ; Bueno-de-Mesquita, Bas ; Peeters, Petra H ; Weiderpass, Elisabete ; Skeie, Guri ; Nøst, Theresa H ; Lasheras, Cristina ; Rodríguez-Barranco, Miguel ; Amiano, Pilar ; Chirlaque, María-Dolores ; Ardanaz, Eva ; Ohlsson, Bodil ; Dias, Joana A ; Nilsson, Lena M ; Myte, Robin ; Khaw, Kay-Tee ; Perez-Cornago, Aurora ; Gunter, Marc ; Huybrechts, Inge ; Cross, Amanda J ; Tsilidis, Kostas ; Riboli, Elio ; Jakszyn, Paula. / Inflammatory potential of the diet and risk of gastric cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. In: American Journal of Clinical Nutrition. 2018 ; Vol. 107, No. 4. pp. 607-616.
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abstract = "Background: Chronic inflammation plays a critical role in the pathogenesis of the 2 major types of gastric cancer. Several foods, nutrients, and nonnutrient food components seem to be involved in the regulation of chronic inflammation.Objective: We assessed the association between the inflammatory potential of the diet and the risk of gastric carcinoma, overall and for the 2 major subsites: cardia cancers and noncardia cancers.Design: A total of 476,160 subjects (30{\%} men, 70{\%} women) from the European Investigation into Cancer and Nutrition (EPIC) study were followed for 14 y, during which 913 incident cases of gastric carcinoma were identified, including 236 located in the cardia, 341 in the distal part of the stomach (noncardia), and 336 with overlapping or unknown tumor site. The dietary inflammatory potential was assessed by means of an inflammatory score of the diet (ISD), calculated with the use of 28 dietary components and their corresponding inflammatory scores. The association between the ISD and gastric cancer risk was estimated by HRs and 95{\%} CIs calculated by multivariate Cox regression models adjusted for confounders.Results: The inflammatory potential of the diet was associated with an increased risk of gastric cancer. The HR (95{\%} CI) for each increase in 1 SD of the ISD were 1.25 (1.12, 1.39) for all gastric cancers, 1.30 (1.06, 1.59) for cardia cancers, and 1.07 (0.89, 1.28) for noncardia cancers. The corresponding values for the highest compared with the lowest quartiles of the ISD were 1.66 (1.26, 2.20), 1.94 (1.14, 3.30), and 1.07 (0.70, 1.70), respectively.Conclusions: Our results suggest that low-grade chronic inflammation induced by the diet may be associated with gastric cancer risk. This pattern seems to be more consistent for gastric carcinomas located in the cardia than for those located in the distal stomach. This study is listed on the ISRCTN registry as ISRCTN12136108.",
author = "Antonio Agudo and Valerie Cayssials and Catalina Bonet and Anne Tj{\o}nneland and Kim Overvad and Marie-Christine Boutron-Ruault and Aur{\'e}lie Affret and Guy Fagherazzi and Verena Katzke and Ruth Sch{\"u}bel and Antonia Trichopoulou and Anna Karakatsani and {La Vecchia}, Carlo and Domenico Palli and Sara Grioni and Rosario Tumino and Fulvio Ricceri and Salvatore Panico and Bas Bueno-de-Mesquita and Peeters, {Petra H} and Elisabete Weiderpass and Guri Skeie and N{\o}st, {Theresa H} and Cristina Lasheras and Miguel Rodr{\'i}guez-Barranco and Pilar Amiano and Mar{\'i}a-Dolores Chirlaque and Eva Ardanaz and Bodil Ohlsson and Dias, {Joana A} and Nilsson, {Lena M} and Robin Myte and Kay-Tee Khaw and Aurora Perez-Cornago and Marc Gunter and Inge Huybrechts and Cross, {Amanda J} and Kostas Tsilidis and Elio Riboli and Paula Jakszyn",
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TY - JOUR

T1 - Inflammatory potential of the diet and risk of gastric cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) study

AU - Agudo, Antonio

AU - Cayssials, Valerie

AU - Bonet, Catalina

AU - Tjønneland, Anne

AU - Overvad, Kim

AU - Boutron-Ruault, Marie-Christine

AU - Affret, Aurélie

AU - Fagherazzi, Guy

AU - Katzke, Verena

AU - Schübel, Ruth

AU - Trichopoulou, Antonia

AU - Karakatsani, Anna

AU - La Vecchia, Carlo

AU - Palli, Domenico

AU - Grioni, Sara

AU - Tumino, Rosario

AU - Ricceri, Fulvio

AU - Panico, Salvatore

AU - Bueno-de-Mesquita, Bas

AU - Peeters, Petra H

AU - Weiderpass, Elisabete

AU - Skeie, Guri

AU - Nøst, Theresa H

AU - Lasheras, Cristina

AU - Rodríguez-Barranco, Miguel

AU - Amiano, Pilar

AU - Chirlaque, María-Dolores

AU - Ardanaz, Eva

AU - Ohlsson, Bodil

AU - Dias, Joana A

AU - Nilsson, Lena M

AU - Myte, Robin

AU - Khaw, Kay-Tee

AU - Perez-Cornago, Aurora

AU - Gunter, Marc

AU - Huybrechts, Inge

AU - Cross, Amanda J

AU - Tsilidis, Kostas

AU - Riboli, Elio

AU - Jakszyn, Paula

PY - 2018/4/1

Y1 - 2018/4/1

N2 - Background: Chronic inflammation plays a critical role in the pathogenesis of the 2 major types of gastric cancer. Several foods, nutrients, and nonnutrient food components seem to be involved in the regulation of chronic inflammation.Objective: We assessed the association between the inflammatory potential of the diet and the risk of gastric carcinoma, overall and for the 2 major subsites: cardia cancers and noncardia cancers.Design: A total of 476,160 subjects (30% men, 70% women) from the European Investigation into Cancer and Nutrition (EPIC) study were followed for 14 y, during which 913 incident cases of gastric carcinoma were identified, including 236 located in the cardia, 341 in the distal part of the stomach (noncardia), and 336 with overlapping or unknown tumor site. The dietary inflammatory potential was assessed by means of an inflammatory score of the diet (ISD), calculated with the use of 28 dietary components and their corresponding inflammatory scores. The association between the ISD and gastric cancer risk was estimated by HRs and 95% CIs calculated by multivariate Cox regression models adjusted for confounders.Results: The inflammatory potential of the diet was associated with an increased risk of gastric cancer. The HR (95% CI) for each increase in 1 SD of the ISD were 1.25 (1.12, 1.39) for all gastric cancers, 1.30 (1.06, 1.59) for cardia cancers, and 1.07 (0.89, 1.28) for noncardia cancers. The corresponding values for the highest compared with the lowest quartiles of the ISD were 1.66 (1.26, 2.20), 1.94 (1.14, 3.30), and 1.07 (0.70, 1.70), respectively.Conclusions: Our results suggest that low-grade chronic inflammation induced by the diet may be associated with gastric cancer risk. This pattern seems to be more consistent for gastric carcinomas located in the cardia than for those located in the distal stomach. This study is listed on the ISRCTN registry as ISRCTN12136108.

AB - Background: Chronic inflammation plays a critical role in the pathogenesis of the 2 major types of gastric cancer. Several foods, nutrients, and nonnutrient food components seem to be involved in the regulation of chronic inflammation.Objective: We assessed the association between the inflammatory potential of the diet and the risk of gastric carcinoma, overall and for the 2 major subsites: cardia cancers and noncardia cancers.Design: A total of 476,160 subjects (30% men, 70% women) from the European Investigation into Cancer and Nutrition (EPIC) study were followed for 14 y, during which 913 incident cases of gastric carcinoma were identified, including 236 located in the cardia, 341 in the distal part of the stomach (noncardia), and 336 with overlapping or unknown tumor site. The dietary inflammatory potential was assessed by means of an inflammatory score of the diet (ISD), calculated with the use of 28 dietary components and their corresponding inflammatory scores. The association between the ISD and gastric cancer risk was estimated by HRs and 95% CIs calculated by multivariate Cox regression models adjusted for confounders.Results: The inflammatory potential of the diet was associated with an increased risk of gastric cancer. The HR (95% CI) for each increase in 1 SD of the ISD were 1.25 (1.12, 1.39) for all gastric cancers, 1.30 (1.06, 1.59) for cardia cancers, and 1.07 (0.89, 1.28) for noncardia cancers. The corresponding values for the highest compared with the lowest quartiles of the ISD were 1.66 (1.26, 2.20), 1.94 (1.14, 3.30), and 1.07 (0.70, 1.70), respectively.Conclusions: Our results suggest that low-grade chronic inflammation induced by the diet may be associated with gastric cancer risk. This pattern seems to be more consistent for gastric carcinomas located in the cardia than for those located in the distal stomach. This study is listed on the ISRCTN registry as ISRCTN12136108.

U2 - 10.1093/ajcn/nqy002

DO - 10.1093/ajcn/nqy002

M3 - Article

VL - 107

SP - 607

EP - 616

JO - American Journal of Clinical Nutrition

JF - American Journal of Clinical Nutrition

SN - 0002-9165

IS - 4

ER -