TY - JOUR
T1 - Inflammatory status and endothelial function in asymptomatic and symptomatic peripheral arterial disease
AU - Silvestro, Antonio
AU - Scopacasa, Francesco
AU - Ruocco, Aldo
AU - Oliva, Gabriella
AU - Schiano, Vittorio
AU - Zincarelli, Carmela
AU - Brevetti, Gregorio
PY - 2003
Y1 - 2003
N2 - Peripheral arterial disease (PAD) is a predictor of cardiovascular risk. However, it is unknown whether PAD severity influences inflammatory status and endothelial function, which play a major role in atherosclerosis. Accordingly, we measured brachial artery flow-mediated dilation (FMD), and plasma levels of several inflammatory markers in 15 control subjects, and 19 asymptomatic and 19 symptomatic PAD patients. Each symptomatic patient was matched to an asymptomatic patient for age, sex, risk factors, presence of cardiovascular disease, and pharmacological treatments. Asymptomatic patients had similar inflammatory profiles as controls, but lower median FMD (11.7% vs 8.5%, p <0.01). Compared with asymptomatic patients, symptomatic patients had higher median C-reactive protein (1.5 mg/I vs 6.0 mg/I, p <0.05) and interleukine-6 (1.5 pg/ml vs 3.5 pg/ml, p <0.05), and lower FMD (8.5% vs 5.1%, p <0.01). In the 38 PAD patients, the ankle/brachial pressure index correlated positively with FMD (p <0.01), and negatively with C-reactive protein (p <0.05), soluble intercellular adhesion molecule-1 (p <0.05) and soluble vascular cell adhesion molecule-1 (p <0.05). Thus, in PAD, endothelial function and inflammatory status are related to the severity of the circulatory impairment. This finding may contribute to the explanation of the increasingly poor prognosis with increased PAD severity.
AB - Peripheral arterial disease (PAD) is a predictor of cardiovascular risk. However, it is unknown whether PAD severity influences inflammatory status and endothelial function, which play a major role in atherosclerosis. Accordingly, we measured brachial artery flow-mediated dilation (FMD), and plasma levels of several inflammatory markers in 15 control subjects, and 19 asymptomatic and 19 symptomatic PAD patients. Each symptomatic patient was matched to an asymptomatic patient for age, sex, risk factors, presence of cardiovascular disease, and pharmacological treatments. Asymptomatic patients had similar inflammatory profiles as controls, but lower median FMD (11.7% vs 8.5%, p <0.01). Compared with asymptomatic patients, symptomatic patients had higher median C-reactive protein (1.5 mg/I vs 6.0 mg/I, p <0.05) and interleukine-6 (1.5 pg/ml vs 3.5 pg/ml, p <0.05), and lower FMD (8.5% vs 5.1%, p <0.01). In the 38 PAD patients, the ankle/brachial pressure index correlated positively with FMD (p <0.01), and negatively with C-reactive protein (p <0.05), soluble intercellular adhesion molecule-1 (p <0.05) and soluble vascular cell adhesion molecule-1 (p <0.05). Thus, in PAD, endothelial function and inflammatory status are related to the severity of the circulatory impairment. This finding may contribute to the explanation of the increasingly poor prognosis with increased PAD severity.
KW - Adhesion molecules
KW - Endothelial dysfunction
KW - Inflammation
KW - Peripheral arterial disease
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U2 - 10.1191/1358863x03vm503oa
DO - 10.1191/1358863x03vm503oa
M3 - Article
C2 - 15125481
AN - SCOPUS:2342537845
VL - 8
SP - 225
EP - 232
JO - Vascular Medicine
JF - Vascular Medicine
SN - 1358-863X
IS - 4
ER -