Infliximab-related seizures: A first case study

Francesco Brigo, Luigi Giuseppe Bongiovanni, Roberto Cerini, Paolo Manganotti, Monica Storti, Antonio Fiaschi

Research output: Contribution to journalArticlepeer-review


Seizures following infliximab treatment are very rare and, to date, there is no detailed description of EEG abnormalities with cerebral radiological findings reported in cases with infliximab-related seizures. We describe a patient who acutely developed seizures temporally related to infliximab treatment, which disappeared after drug withdrawal. MRI showed encephalopathy involving mainly cortical regions and EEGs showed focal paroxysmal activity which completely disappeared a few days after infliximab withdrawal. No other plausible cause of the seizures was identified. The clear temporal association between seizure onset and infliximab treatment as well as the clinical improvement and disappearance of focal epileptiform activity after drug withdrawal indicated an evident correlation between seizures and infliximab therapy. The coexistence of pathological findings on MRI suggested that seizures were secondary to the encephalopathy. Further studies are required to evaluate whether infliximab per se has an epileptogenic effect or whether the seizures are caused by encephalopathy involving cortico-subcortical regions.

Original languageEnglish
Pages (from-to)214-217
Number of pages4
JournalEpileptic Disorders
Issue number2
Publication statusPublished - Jun 2011


  • EEG
  • grey matter encephalopathy
  • infliximab
  • posterior reversible encephalopathy syndrome
  • seizures
  • TNF-α antagonists

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology


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