Influence of 5-HTTLPR and TPH variants on illness time course in mood disorders

Cristina Cusin, Alessandro Serretti, Enrico Lattuada, Roberta Lilli, Cristina Lorenzi, Laura Mandelli, Elisa Pisati, Enrico Smeraldi

Research output: Contribution to journalArticlepeer-review


The aim of our study was to investigate gene variants in the long-term outcome of mood disorders. We retrospectively studied a sample of inpatients affected by recurrent and rapid cycling mood disorders. The serotonin transporter gene-linked functional polymorphic region (5-HTTLPR) and the A218C tryptophan hydroxylase (TPH) gene variant were determined using a PCR-based technique. For 5-HTTLPR polymorphism we genotyped 435 inpatients affected by major depressive (n=153), bipolar (n=213) and rapid cycling (n=69) mood disorders and 456 controls; for TPH we genotyped 399 inpatients (MD, n=132; BP, n=203; rapid cycling n=64) and 259 controls. Random Regression Model analysis was used to investigate the longitudinal time course of the illness. 5-HTTLPR and TPH polymorphisms were not associated with mood disorders time course. However we observed an excess of 5-HTTLPR*long alleles among rapid cycling subjects compared to both controls (P=0.018) and remitting mood disorders (P=0.006). TPH frequencies did not differ between mood disorders subtypes. Our results suggest that 5-HTTLPR variants may confer a susceptibility toward rapid cycling mood disorders.

Original languageEnglish
Pages (from-to)217-223
Number of pages7
JournalJournal of Psychiatric Research
Issue number4
Publication statusPublished - 2001


  • Bipolar disorder
  • Depressive disorder
  • Follow-up studies
  • Genetics
  • Rapid cycling

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry
  • Psychology(all)


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