Influence of 5-HTTLPR and TPH variants on illness time course in mood disorders

Cristina Cusin, Alessandro Serretti, Enrico Lattuada, Roberta Lilli, Cristina Lorenzi, Laura Mandelli, Elisa Pisati, Enrico Smeraldi

Research output: Contribution to journalArticle

Abstract

The aim of our study was to investigate gene variants in the long-term outcome of mood disorders. We retrospectively studied a sample of inpatients affected by recurrent and rapid cycling mood disorders. The serotonin transporter gene-linked functional polymorphic region (5-HTTLPR) and the A218C tryptophan hydroxylase (TPH) gene variant were determined using a PCR-based technique. For 5-HTTLPR polymorphism we genotyped 435 inpatients affected by major depressive (n=153), bipolar (n=213) and rapid cycling (n=69) mood disorders and 456 controls; for TPH we genotyped 399 inpatients (MD, n=132; BP, n=203; rapid cycling n=64) and 259 controls. Random Regression Model analysis was used to investigate the longitudinal time course of the illness. 5-HTTLPR and TPH polymorphisms were not associated with mood disorders time course. However we observed an excess of 5-HTTLPR*long alleles among rapid cycling subjects compared to both controls (P=0.018) and remitting mood disorders (P=0.006). TPH frequencies did not differ between mood disorders subtypes. Our results suggest that 5-HTTLPR variants may confer a susceptibility toward rapid cycling mood disorders.

Original languageEnglish
Pages (from-to)217-223
Number of pages7
JournalJournal of Psychiatric Research
Volume35
Issue number4
DOIs
Publication statusPublished - 2001

Fingerprint

Tryptophan Hydroxylase
Mood Disorders
Inpatients
Genes
Serotonin Plasma Membrane Transport Proteins
Alleles
Regression Analysis
Polymerase Chain Reaction

Keywords

  • Bipolar disorder
  • Depressive disorder
  • Follow-up studies
  • Genetics
  • Rapid cycling

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry
  • Psychology(all)

Cite this

Influence of 5-HTTLPR and TPH variants on illness time course in mood disorders. / Cusin, Cristina; Serretti, Alessandro; Lattuada, Enrico; Lilli, Roberta; Lorenzi, Cristina; Mandelli, Laura; Pisati, Elisa; Smeraldi, Enrico.

In: Journal of Psychiatric Research, Vol. 35, No. 4, 2001, p. 217-223.

Research output: Contribution to journalArticle

Cusin, C, Serretti, A, Lattuada, E, Lilli, R, Lorenzi, C, Mandelli, L, Pisati, E & Smeraldi, E 2001, 'Influence of 5-HTTLPR and TPH variants on illness time course in mood disorders', Journal of Psychiatric Research, vol. 35, no. 4, pp. 217-223. https://doi.org/10.1016/S0022-3956(01)00026-7
Cusin, Cristina ; Serretti, Alessandro ; Lattuada, Enrico ; Lilli, Roberta ; Lorenzi, Cristina ; Mandelli, Laura ; Pisati, Elisa ; Smeraldi, Enrico. / Influence of 5-HTTLPR and TPH variants on illness time course in mood disorders. In: Journal of Psychiatric Research. 2001 ; Vol. 35, No. 4. pp. 217-223.
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