Influence of age on response to controlled ovarian stimulation in women with low levels of serum anti-Müllerian hormone

Claudia Massarotti, Valentina La Pica, Fausta Sozzi, Paola Scaruffi, Valentino Remorgida, Paola Anserini

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This study aims at detecting and evaluating differences in quantitative response to controlled ovarian stimulation (COS) with high doses of gonadotropins in women with low serum anti-Müllerian hormone (AMH). About 369 first cycles in a real-life scenario in women between 21 and 43 years old and with AMH ≤0.9 ng/ml were analyzed. Older women had a significantly worse outcome with respect to young women, not only qualitatively, but also in terms of quantitative ovarian response to COS [odd ratio (OR) to obtain at least three MII oocytes with each increasing year of female age: 0.89, 95% CI: 0.85 − 0.94; p <.001]. This study endorses that age is a significant factor when counseling patients with low AMH. AMH levels per se are not a reason to exclude patients from a COS treatment, since pregnancy and live birth can be achieved, especially in younger patients. However, with an AMH equally low, the ovarian response worsens with age, making questionable the effectiveness of a stimulation with high-dose gonadotropins in the older subgroup.

Original languageEnglish
JournalGynecological Endocrinology
Publication statusAccepted/In press - Jan 1 2020



  • AntiMullerian hormone (AMH)
  • controlled ovarian stimulation
  • IVF
  • ovarian reserve

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology
  • Obstetrics and Gynaecology

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