Influence of antibiotic treatment on breast carcinoma development in proto-neu transgenic mice

Anna Rossini, Cristiano Rumio, Lucia Sfondrini, Elda Tagliabue, Daniele Morelli, Rosalba Miceli, Luigi Mariani, Marco Palazzo, Sylvie Ménard, Andrea Balsari

Research output: Contribution to journalArticlepeer-review

Abstract

The effect of prolonged antibiotic treatments on tumor development was evaluated in proto-neu transgenic mice, which spontaneously develop mammary carcinomas. Virgin transgenic mice were treated with metronidazole/ciprofloxacin or gentamicin through the drinking water. The hazard ratio [HR; 95% confidence interval (95% CI)] of breast cancer occurrence in metronidazole/ciprofloxacin- treated mice was more than triple that for controls [3.11 (1.13-8.53); P = 0.028], whereas only a slight increase in HR (95% CI) was observed in genfcunicin-treated mice [1.39 (0.56-3.47); P = 0.481]. Tumor growth rate in gentamicin-treated mice was significantly faster than in untreated control mice (P = 0.043). Moreover, mammary glands from mice treated with either antibiotic regimen showed increased lobulization, with more numerous and more developed terminal ductal lobular units than in controls. These results indicate that prolonged exposure to relevant doses of antibiotics affects the mammary glands in this particular model of HER-2/neu transgenic mice; further studies to understand the precise mechanism by which antibiotic treatments influence mammary gland differentiation are critical.

Original languageEnglish
Pages (from-to)6219-6224
Number of pages6
JournalCancer Research
Volume66
Issue number12
DOIs
Publication statusPublished - Jun 15 2006

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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