Influence of arterial hypertension, type 2 diabetes and cardiovascular risk factors on ALS outcome: a population-based study

Cristina Moglia, Andrea Calvo, Antonio Canosa, Davide Bertuzzo, Paolo Cugnasco, Luca Solero, Maurizio Grassano, Enrica Bersano, Stefania Cammarosano, Umberto Manera, Fabrizio Pisano, Letizia Mazzini, Laura A Dalla Vecchia, Gabriele Mora, Adriano Chiò, Parals

Research output: Contribution to journalArticle

Abstract

OBJECTIVE: To assess the prognostic influence of pre-morbid type 2 diabetes mellitus, arterial hypertension and cardiovascular (CV) risk profile on ALS phenotype and outcome in a population-based cohort of Italian patients.

METHODS: A total of 650 ALS patients from the Piemonte/Valle d'Aosta Register for ALS, incident in the 2007-2011 period, were recruited. Information about premorbid presence of type 2 diabetes mellitus, arterial hypertension was collected at the time of diagnosis. Patients' CV risk profile was calculated according to the Joint British Societies' guidelines on prevention of cardiovascular disease in clinical practice (JBS2).

RESULTS: At the univariate analysis, the presence of pre-morbid arterial hypertension was associated with a higher age at onset of ALS and a shorter survival, and patients with a high CV risk profile had a worse prognosis than those with a low CV risk profile. The Cox multivariable analysis did not confirm such findings. Type 2 diabetes mellitus did not modify either the phenotype or the prognosis of ALS patients.

CONCLUSIONS: This study performed on a large population-based cohort of ALS patients has demonstrated that arterial hypertension, type 2 diabetes and CV risk factors, calculated using the Framingham equation, do not influence ALS phenotype and prognosis.

Original languageEnglish
Pages (from-to)590-597
Number of pages8
JournalAmyotrophic Lateral Sclerosis and Frontotemporal Degeneration
Volume18
Issue number7-8
DOIs
Publication statusPublished - Nov 2017

Keywords

  • Journal Article

Fingerprint Dive into the research topics of 'Influence of arterial hypertension, type 2 diabetes and cardiovascular risk factors on ALS outcome: a population-based study'. Together they form a unique fingerprint.

  • Cite this

    Moglia, C., Calvo, A., Canosa, A., Bertuzzo, D., Cugnasco, P., Solero, L., Grassano, M., Bersano, E., Cammarosano, S., Manera, U., Pisano, F., Mazzini, L., Dalla Vecchia, L. A., Mora, G., Chiò, A., & Parals (2017). Influence of arterial hypertension, type 2 diabetes and cardiovascular risk factors on ALS outcome: a population-based study. Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, 18(7-8), 590-597. https://doi.org/10.1080/21678421.2017.1336560