Influence of baseline ejection fraction on the prognostic value of paravalvular leak after transcatheter aortic valve implantation

Sakiko Miyazaki, Eustachio Agricola, Vasileios F. Panoulas, Massimo Slavich, Gennaro Giustino, Tadashi Miyazaki, Filippo Figini, Azeem Latib, Alaide Chieffo, Matteo Montorfano, Alberto Margonato, Francesco Maisano, Ottavio Alfieri, Antonio Colombo

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Moderate or severe paravalvular leak (PVL ≥ moderate) after transcatheter aortic valve implantation (TAVI) is associated with poor outcomes. The aim of this study was to assess whether the baseline ejection fraction (EF) affects the impact of PVL on mortality after TAVI. Methods: Weanalyzed 514 consecutive patients with native severe aortic stenosis who underwent TAVI. Patients were divided into two groups: EF b40% group (n = 84) and EF ≥40% group (n = 430) according to baseline EF. Results: The mean age was 79.5 years and 49% were male. Patients in the EF b40% group were younger and with higher logistic EuroSCORE compared to patients in the EF ≥40% group. Diabetes, coronary artery disease, atrial fibrillation and renal insufficiency were more prevalent in the EF b40% group. Patients in the EF b40% group had more mitral regurgitation. In-hospital mortality was significantly higher in the EF b40% group (8.3% vs. 0.9%, p b 0.0001). PVL ≥ moderate was significantly associated with increased 2-year estimated mortality only in the EF b40% group (65% vs. 20%, log-rank p b 0.0001) whereas no difference was seen in the EF ≥40% group (24% vs. 19%, log-rank p = 0.509). Interaction between PVL ≥ moderate and EF b40% was statistically significant. Conclusions: The impact of PVL ≥moderateonmortality after TAVI was significantin the EF b40% group but not in the EF ≥40% group in our study. Even though operators should aim to minimize PVL in all TAVI patients, special attention is required for patients with reduced baseline EF.

Original languageEnglish
Pages (from-to)277-281
Number of pages5
JournalInternational Journal of Cardiology
Volume190
Issue number1
DOIs
Publication statusPublished - Jul 1 2015

Keywords

  • 2-Year mortality
  • Aortic stenosis
  • Left ventricular ejection fraction
  • Paravalvular leak
  • Transcatheter aortic valve implantation

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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