Background: Moderate or severe paravalvular leak (PVL ≥ moderate) after transcatheter aortic valve implantation (TAVI) is associated with poor outcomes. The aim of this study was to assess whether the baseline ejection fraction (EF) affects the impact of PVL on mortality after TAVI. Methods: Weanalyzed 514 consecutive patients with native severe aortic stenosis who underwent TAVI. Patients were divided into two groups: EF b40% group (n = 84) and EF ≥40% group (n = 430) according to baseline EF. Results: The mean age was 79.5 years and 49% were male. Patients in the EF b40% group were younger and with higher logistic EuroSCORE compared to patients in the EF ≥40% group. Diabetes, coronary artery disease, atrial fibrillation and renal insufficiency were more prevalent in the EF b40% group. Patients in the EF b40% group had more mitral regurgitation. In-hospital mortality was significantly higher in the EF b40% group (8.3% vs. 0.9%, p b 0.0001). PVL ≥ moderate was significantly associated with increased 2-year estimated mortality only in the EF b40% group (65% vs. 20%, log-rank p b 0.0001) whereas no difference was seen in the EF ≥40% group (24% vs. 19%, log-rank p = 0.509). Interaction between PVL ≥ moderate and EF b40% was statistically significant. Conclusions: The impact of PVL ≥moderateonmortality after TAVI was significantin the EF b40% group but not in the EF ≥40% group in our study. Even though operators should aim to minimize PVL in all TAVI patients, special attention is required for patients with reduced baseline EF.
- 2-Year mortality
- Aortic stenosis
- Left ventricular ejection fraction
- Paravalvular leak
- Transcatheter aortic valve implantation
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine