Valutazione scintigrafica con metodica SPECT dell'effetto dei bifosfonati sul processo di osseointegrazione implantare.

Translated title of the contribution: Influence of biphosphonates on the integration process of endosseous implants evaluated using single photon emission computerized tomography (SPECT)

F. Bambini, C. A. De Stefano, L. Giannotti, L. Memè, M. Pellecchia

Research output: Contribution to journalArticle

Abstract

Biphosphonates are a large class of drugs which inhibits the resorbing activity of osteoclasts. The aim of this study was to evaluate the influence of topical application of the biphosphonate alendronate on the integration process of endosseus implants placed in a partially edentulous patient. After incision and elevation of a mucoperiosteal flap and carrying out the osteotomy, 2 SLA implants 10 mm long and 3.5 mm wide were inserted in the area of # 4.5 and 4.6. Before placement of # 4.5, a paste made of grinded tablets of alendronate and Rifocin was applied in the osteotomy. Fifteen days after stage I, an evaluation of the osteoblastic peri-implant activity was carried out using single photon emission computerized tomography. Healing was within normal limits. Four months after stage I, the 2 implants were uncovered and considered clinically and radiographically integrated. The osteoblastic activity was judged similar bet-ween the 2 implants in terms of quality of biological response. Osseous scintigraphy and the achievement of implant osseointegration demonstrate the lack of toxicity of the topical application of the biphosphonate alendronate during the initial osseous healing. However, new experimental studies and clinical trials are necessary to confirm the results obtained.

Translated title of the contributionInfluence of biphosphonates on the integration process of endosseous implants evaluated using single photon emission computerized tomography (SPECT)
Original languageItalian
Pages (from-to)331-338
Number of pages8
JournalMinerva Stomatologica
Volume52
Issue number6
Publication statusPublished - 2003

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