Influence of body surface area on serum peak thyrotropin (TSH) levels after recombinant human TSH administration

Giovanni Vitale, Gelsy Arianna Lupoli, Antonio Ciccarelli, Antonio Lucariello, Maria Rosa Fittipaldi, Francesco Fonderico, Annalisa Panico, Giovanni Lupoli

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Recombinant human TSH (rhTSH) has been proposed as an alternative method to the withdrawal of thyroid hormones in the follow-up of differentiated thyroid cancer. The aim of the present study was to evaluate the influence of several demographic and anthropometric parameters [age, body weight, height, body mass index, and body surface area (BSA)] on serum peak TSH levels after rhTSH administration. rhTSH was administered to 112 patients with differentiated thyroid carcinoma according to the conventional two-dose schedule (0.9 mg/d). Serum TSH levels were measured 24 h before and after the first administration of rhTSH, and then 24, 48, and 72 h after the second administration of rhTSH. In one severely obese patient, serum peak TSH values did not reach a valid stimulation range. Serum peak TSH levels were negatively related to body weight (r = -0.69; P <0.0001), body mass index (r = -0.51; P <0.0001), and BSA (r = -0.72; P <0.0001). In a multivariate regression analysis including demographic and anthropometric variables, only BSA was independently associated to serum peak TSH concentrations (standardized β coefficient = -0.721; P <0.0001). In conclusion, body size seems to influence serum peak TSH levels after rhTSH administration. Future studies should evaluate the possibility of using personalized rhTSH doses, adjusted in relation to BSA.

Original languageEnglish
Pages (from-to)1319-1322
Number of pages4
JournalJournal of Clinical Endocrinology and Metabolism
Volume88
Issue number3
DOIs
Publication statusPublished - Mar 1 2003

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Thyrotropin Alfa
Body Surface Area
Thyrotropin
Serum
Thyroid Neoplasms
Body Mass Index
Body Weight
Demography
Body Height
Body Size
Thyroid Hormones
Regression analysis
Appointments and Schedules
Multivariate Analysis
Regression Analysis

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology, Diabetes and Metabolism

Cite this

Influence of body surface area on serum peak thyrotropin (TSH) levels after recombinant human TSH administration. / Vitale, Giovanni; Lupoli, Gelsy Arianna; Ciccarelli, Antonio; Lucariello, Antonio; Fittipaldi, Maria Rosa; Fonderico, Francesco; Panico, Annalisa; Lupoli, Giovanni.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 88, No. 3, 01.03.2003, p. 1319-1322.

Research output: Contribution to journalArticle

Vitale, G, Lupoli, GA, Ciccarelli, A, Lucariello, A, Fittipaldi, MR, Fonderico, F, Panico, A & Lupoli, G 2003, 'Influence of body surface area on serum peak thyrotropin (TSH) levels after recombinant human TSH administration', Journal of Clinical Endocrinology and Metabolism, vol. 88, no. 3, pp. 1319-1322. https://doi.org/10.1210/jc.2002-020953
Vitale, Giovanni ; Lupoli, Gelsy Arianna ; Ciccarelli, Antonio ; Lucariello, Antonio ; Fittipaldi, Maria Rosa ; Fonderico, Francesco ; Panico, Annalisa ; Lupoli, Giovanni. / Influence of body surface area on serum peak thyrotropin (TSH) levels after recombinant human TSH administration. In: Journal of Clinical Endocrinology and Metabolism. 2003 ; Vol. 88, No. 3. pp. 1319-1322.
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