Influence of CAG repeat polymorphism on the targets of testosterone action

Giacomo Tirabassi, Angelo Cignarelli, Sebastio Perrini, Nicola Delli Muti, Giorgio Furlani, Mariagrazia Gallo, Francesco Pallotti, Donatella Paoli, Francesco Giorgino, Francesco Lombardo, Loredana Gandini, Andrea Lenzi, Giancarlo Balercia

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

In the last decade, ample evidence has demonstrated the growing importance of androgen receptor (AR) CAG repeat polymorphism in andrology. This genetic parameter is able to condition the peripheral effects of testosterone and therefore to influence male sexual function and fertility, cardiovascular risk, body composition, bone metabolism, the risk of prostate and testicular cancer, the psychiatric status, and the onset of neurodegenerative disorders. In this review, we extensively discuss the literature data and identify a role for AR CAG repeat polymorphism in conditioning the systemic testosterone effects. In particular, our main purpose was to provide an updated text able to shed light on the many and often contradictory findings reporting an influence of CAG repeat polymorphism on the targets of testosterone action.

Original languageEnglish
Article number298107
JournalInternational Journal of Endocrinology
Volume2015
DOIs
Publication statusPublished - 2015

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Testosterone
Androgen Receptors
Andrology
Testicular Neoplasms
Body Composition
Neurodegenerative Diseases
Fertility
Psychiatry
Prostatic Neoplasms
Bone and Bones

ASJC Scopus subject areas

  • Endocrine and Autonomic Systems
  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Tirabassi, G., Cignarelli, A., Perrini, S., Delli Muti, N., Furlani, G., Gallo, M., ... Balercia, G. (2015). Influence of CAG repeat polymorphism on the targets of testosterone action. International Journal of Endocrinology, 2015, [298107]. https://doi.org/10.1155/2015/298107

Influence of CAG repeat polymorphism on the targets of testosterone action. / Tirabassi, Giacomo; Cignarelli, Angelo; Perrini, Sebastio; Delli Muti, Nicola; Furlani, Giorgio; Gallo, Mariagrazia; Pallotti, Francesco; Paoli, Donatella; Giorgino, Francesco; Lombardo, Francesco; Gandini, Loredana; Lenzi, Andrea; Balercia, Giancarlo.

In: International Journal of Endocrinology, Vol. 2015, 298107, 2015.

Research output: Contribution to journalArticle

Tirabassi, G, Cignarelli, A, Perrini, S, Delli Muti, N, Furlani, G, Gallo, M, Pallotti, F, Paoli, D, Giorgino, F, Lombardo, F, Gandini, L, Lenzi, A & Balercia, G 2015, 'Influence of CAG repeat polymorphism on the targets of testosterone action', International Journal of Endocrinology, vol. 2015, 298107. https://doi.org/10.1155/2015/298107
Tirabassi G, Cignarelli A, Perrini S, Delli Muti N, Furlani G, Gallo M et al. Influence of CAG repeat polymorphism on the targets of testosterone action. International Journal of Endocrinology. 2015;2015. 298107. https://doi.org/10.1155/2015/298107
Tirabassi, Giacomo ; Cignarelli, Angelo ; Perrini, Sebastio ; Delli Muti, Nicola ; Furlani, Giorgio ; Gallo, Mariagrazia ; Pallotti, Francesco ; Paoli, Donatella ; Giorgino, Francesco ; Lombardo, Francesco ; Gandini, Loredana ; Lenzi, Andrea ; Balercia, Giancarlo. / Influence of CAG repeat polymorphism on the targets of testosterone action. In: International Journal of Endocrinology. 2015 ; Vol. 2015.
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