Influence of clinical variables on neuropsychological performance in multiple sclerosis

Massimo Filippi, Margherita Alberoni, Vittorio Martinelli, Graziella Sirabian, Sergio Bressi, Nicola Canal, Giancarlo Comi

Research output: Contribution to journalArticlepeer-review


The effects of age. educational level, duration and course of the disease, physical disability and mood status on several cognitive functions (short- and longterm memory, frontal functions, attention, language and visuospatial skills) have been evaluated in 42 multiple sclerosis (MS) patients. The Hamilton Depression Rating Scale (HDRS) scores and a secondary progressive disease course significantly influenced neuropsychological performance. Factorial analysis revealed that indexes of (1) frontal function impairment, (2) longterm verbal memory and language function impairment, and (3) visuospatial short- and long-term memory and visuoperceptive function impairment accounted for 85% of the variance in neuropsychological performance. Only the first factor was significantly related to the presence of depressive symp-tomatology, as assessed by the HDRS. These results indicate that both the course of the disease and the presence of affective disorders must be taken into account when evaluating the natural history of cognitive impairment in MS and suggest that depressive symptomatology and cognitive dysfunction in MS are related to the involvement of at least partially overlapping anatomofunctional circuits.

Original languageEnglish
Pages (from-to)324-328
Number of pages5
JournalEuropean Neurology
Issue number6
Publication statusPublished - 1994


  • Clinical variables
  • Depression
  • Multiple sclerosis
  • Neuropsychological performance

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology


Dive into the research topics of 'Influence of clinical variables on neuropsychological performance in multiple sclerosis'. Together they form a unique fingerprint.

Cite this