Influence of clinically significant portal hypertension on survival after hepatic resection for hepatocellular carcinoma in cirrhotic patients

Edoardo G. Giannini, Vincenzo Savarino, Fabio Farinati, Francesca Ciccarese, Gianludovico Rapaccini, Mariella Di Marco, Luisa Benvegnù, Marco Zoli, Franco Borzio, Eugenio Caturelli, Maria Chiaramonte, Franco Trevisani

Research output: Contribution to journalArticle

Abstract

Background: The role of clinically significant portal hypertension on the prognosis of cirrhotic patients undergoing hepatic resection for hepatocellular carcinoma (HCC) is debated. Aims: In this study, our aim was to assess the role of clinically significant portal hypertension after hepatic resection for HCC in patients with cirrhosis. Methods: We assessed the prognostic role of the presence of clinically significant portal hypertension (oesophageal/gastric varices/portal hypertensive gastropathy or a platelet count 9/L associated with splenomegaly) in 152 patients with compensated cirrhosis who underwent hepatic resection for HCC at the Italian Liver Cancer centres. Survival rates were assessed in the whole series, in the subgroup of Child-Pugh score 5 patients with uninodular HCC ≤5 cm, and in Child-Pugh score 5 patients with uninodular HCC ≤2 cm and normal bilirubin. Results: Median survival was similar in patients with and without clinically significant portal hypertension (79 vs 77 months, P = 0.686). Child-Pugh score 5 was the only variable significantly associated with survival by Cox multiple regression (P = 0.007). In Child-Pugh score 5 patients with single HCC ≤5 cm or in those with single HCC ≤2 cm and normal bilirubin, there was no survival difference between patients with and without clinically significant portal hypertension (median survival: 94 vs 78 months, P = 0.121 and >100 vs 86 months, P = 0.742). Conclusions: Presence of clinically significant portal hypertension has no influence on survival of patients with well-compensated cirrhosis undergoing hepatic resection for HCC.

Original languageEnglish
Pages (from-to)1594-1600
Number of pages7
JournalLiver International
Volume33
Issue number10
DOIs
Publication statusPublished - Nov 2013

Keywords

  • Hepatic venous pressure gradient
  • Hepatocellular carcinoma
  • Oesophageal varices
  • Portal hypertension
  • Surgery
  • Survival
  • Thrombocytopaenia

ASJC Scopus subject areas

  • Hepatology

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  • Cite this

    Giannini, E. G., Savarino, V., Farinati, F., Ciccarese, F., Rapaccini, G., Marco, M. D., Benvegnù, L., Zoli, M., Borzio, F., Caturelli, E., Chiaramonte, M., & Trevisani, F. (2013). Influence of clinically significant portal hypertension on survival after hepatic resection for hepatocellular carcinoma in cirrhotic patients. Liver International, 33(10), 1594-1600. https://doi.org/10.1111/liv.12199