Influence of coffee drinking and cigarette smoking on the risk of primary late onset blepharospasm

Evidence from a multicentre case control study

Giovanni Defazio, D. Martino, G. Abbruzzese, P. Girlanda, M. Tinazzi, G. Fabbrini, C. Colosimo, M. S. Aniello, L. Avanzino, M. Buccafusca, G. Majorana, C. Trompetto, P. Livrea, A. Berardelli

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Prior coffee and smoking habits were investigated in a multicentre case control study involving 166 patients presenting with primary late onset blepharospasm (BSP), 228 hospital control patients with primary hemifacial spasm and 187 population control subjects from five Italian centres. Information on age at disease onset, smoking and coffee drinking status at the reference age and average number of cups of coffee drunk/cigarettes smoked per day reached high and similar test-retest reproducibility in case and control patients. Unadjusted logistic regression analysis yielded a significant inverse association of prior coffee drinking and cigarette smoking with case status for the control groups. After adjustment for age, sex, referral centre, disease duration, years of schooling and ever coffee drinking/cigarette smoking, as appropriate, the smoking estimate lacked significance whereas the association of coffee intake and BSP did not (cases vs hospital control patients: OR 0.37 (95% CI 0.20 to 0.67); cases vs population control subjects: OR 0.44 (95% CI 0.23 to 0.85)). The strength of the inverse association between BSP and coffee intake tended to increase with the average number of cups drunk per day. There was a significant correlation between age of BSP onset and number of cups per day (adjusted regression coefficient 1.73; p = 0.001) whereas no correlation was found with number of packs of cigarettes per day. Coffee drinking may be inversely associated with the development of primary BSP and this association may partly depend on the amount consumed.

Original languageEnglish
Pages (from-to)877-879
Number of pages3
JournalJournal of Neurology, Neurosurgery and Psychiatry
Volume78
Issue number8
DOIs
Publication statusPublished - Aug 2007

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Blepharospasm
Coffee
Drinking
Case-Control Studies
Smoking
Population Control
Age of Onset
Tobacco Products
Hemifacial Spasm
Habits
Referral and Consultation
Logistic Models
Regression Analysis
Control Groups

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Neuroscience(all)
  • Psychiatry and Mental health

Cite this

Influence of coffee drinking and cigarette smoking on the risk of primary late onset blepharospasm : Evidence from a multicentre case control study. / Defazio, Giovanni; Martino, D.; Abbruzzese, G.; Girlanda, P.; Tinazzi, M.; Fabbrini, G.; Colosimo, C.; Aniello, M. S.; Avanzino, L.; Buccafusca, M.; Majorana, G.; Trompetto, C.; Livrea, P.; Berardelli, A.

In: Journal of Neurology, Neurosurgery and Psychiatry, Vol. 78, No. 8, 08.2007, p. 877-879.

Research output: Contribution to journalArticle

Defazio, G, Martino, D, Abbruzzese, G, Girlanda, P, Tinazzi, M, Fabbrini, G, Colosimo, C, Aniello, MS, Avanzino, L, Buccafusca, M, Majorana, G, Trompetto, C, Livrea, P & Berardelli, A 2007, 'Influence of coffee drinking and cigarette smoking on the risk of primary late onset blepharospasm: Evidence from a multicentre case control study', Journal of Neurology, Neurosurgery and Psychiatry, vol. 78, no. 8, pp. 877-879. https://doi.org/10.1136/jnnp.2007.119891
Defazio, Giovanni ; Martino, D. ; Abbruzzese, G. ; Girlanda, P. ; Tinazzi, M. ; Fabbrini, G. ; Colosimo, C. ; Aniello, M. S. ; Avanzino, L. ; Buccafusca, M. ; Majorana, G. ; Trompetto, C. ; Livrea, P. ; Berardelli, A. / Influence of coffee drinking and cigarette smoking on the risk of primary late onset blepharospasm : Evidence from a multicentre case control study. In: Journal of Neurology, Neurosurgery and Psychiatry. 2007 ; Vol. 78, No. 8. pp. 877-879.
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