Influence of Complex Loading Conditions on Intervertebral Disc Failure

Nikolaus Berger-Roscher, Gloria Casaroli, Volker Rasche, Tomaso Villa, Fabio Galbusera, Hans Joachim Wilke

Research output: Contribution to journalArticle

Abstract

STUDY DESIGN.: High resolution imaging investigation of the failure of ovine lumbar intervertebral discs under complex loading. OBJECTIVE.: To investigate how different loading combinations influence the mechanism and extent of intervertebral disc failure. SUMMARY OF BACKGROUND DATA.: Even though there has been extensive research on how an intervertebral disc fails under various conditions, failure mechanisms remain unclear. In addition, the influence of different loading directions on the mode and extent of failure under complex loading was never systematically investigated. METHODS.: Thirty ovine lumbar spinal segments were loaded in a newly developed, dynamic, 6-DOF disc loading simulator under five combinations of the following loading parameters: 0°-13° flexion, 0°-10° lateral bending, 0°-4° axial rotation, 0 N-800?N axial compression. A total of 1,000 cycles at 2?Hz were done. After testing, imaging of the discs was performed in an ultra-high field MRI (11.7 T) scanner as well as with a μCT scanner. RESULTS.: A total of 13 large endplate junction failures (EPJFs) occurred, of which all but one maintained an intact cartilaginous endplate. 10 out of 13 EPJFs occurred caudally. Four solely annulus failures occurred affecting only the outer posterior annulus. A herniation was not observed. The maximum moments measured in any group (median) were 52.5 Nm flexion, 16.5 Nm lateral bending, and 14.0 Nm axial rotation. CONCLUSIONS.: Complex loading protocols could lead to EPJFs (76%) as well as annulus failures (24%) in vitro. The combination of flexion, lateral bending, axial rotation, and axial compression bears the highest risk for caudal EPJF. Flexion without lateral bending and vice versa has the lowest risk for failure. Both axial compression and axial rotation seem to have a smaller influence than flexion and lateral bending. It seems that a herniation requires an additional failure of the cartilaginous endplate, likely initiated by further axial compressive load.Level of Evidence: 4

Original languageEnglish
Pages (from-to)E78-E85
JournalSpine
Volume42
Issue number2
DOIs
Publication statusPublished - 2017

Fingerprint

Intervertebral Disc
Sheep
Research

ASJC Scopus subject areas

  • Clinical Neurology
  • Orthopedics and Sports Medicine

Cite this

Berger-Roscher, N., Casaroli, G., Rasche, V., Villa, T., Galbusera, F., & Wilke, H. J. (2017). Influence of Complex Loading Conditions on Intervertebral Disc Failure. Spine, 42(2), E78-E85. https://doi.org/10.1097/BRS.0000000000001699

Influence of Complex Loading Conditions on Intervertebral Disc Failure. / Berger-Roscher, Nikolaus; Casaroli, Gloria; Rasche, Volker; Villa, Tomaso; Galbusera, Fabio; Wilke, Hans Joachim.

In: Spine, Vol. 42, No. 2, 2017, p. E78-E85.

Research output: Contribution to journalArticle

Berger-Roscher, N, Casaroli, G, Rasche, V, Villa, T, Galbusera, F & Wilke, HJ 2017, 'Influence of Complex Loading Conditions on Intervertebral Disc Failure', Spine, vol. 42, no. 2, pp. E78-E85. https://doi.org/10.1097/BRS.0000000000001699
Berger-Roscher, Nikolaus ; Casaroli, Gloria ; Rasche, Volker ; Villa, Tomaso ; Galbusera, Fabio ; Wilke, Hans Joachim. / Influence of Complex Loading Conditions on Intervertebral Disc Failure. In: Spine. 2017 ; Vol. 42, No. 2. pp. E78-E85.
@article{f3fa4f40ef534206babbacf5bf91d85e,
title = "Influence of Complex Loading Conditions on Intervertebral Disc Failure",
abstract = "STUDY DESIGN.: High resolution imaging investigation of the failure of ovine lumbar intervertebral discs under complex loading. OBJECTIVE.: To investigate how different loading combinations influence the mechanism and extent of intervertebral disc failure. SUMMARY OF BACKGROUND DATA.: Even though there has been extensive research on how an intervertebral disc fails under various conditions, failure mechanisms remain unclear. In addition, the influence of different loading directions on the mode and extent of failure under complex loading was never systematically investigated. METHODS.: Thirty ovine lumbar spinal segments were loaded in a newly developed, dynamic, 6-DOF disc loading simulator under five combinations of the following loading parameters: 0°-13° flexion, 0°-10° lateral bending, 0°-4° axial rotation, 0 N-800?N axial compression. A total of 1,000 cycles at 2?Hz were done. After testing, imaging of the discs was performed in an ultra-high field MRI (11.7 T) scanner as well as with a μCT scanner. RESULTS.: A total of 13 large endplate junction failures (EPJFs) occurred, of which all but one maintained an intact cartilaginous endplate. 10 out of 13 EPJFs occurred caudally. Four solely annulus failures occurred affecting only the outer posterior annulus. A herniation was not observed. The maximum moments measured in any group (median) were 52.5 Nm flexion, 16.5 Nm lateral bending, and 14.0 Nm axial rotation. CONCLUSIONS.: Complex loading protocols could lead to EPJFs (76{\%}) as well as annulus failures (24{\%}) in vitro. The combination of flexion, lateral bending, axial rotation, and axial compression bears the highest risk for caudal EPJF. Flexion without lateral bending and vice versa has the lowest risk for failure. Both axial compression and axial rotation seem to have a smaller influence than flexion and lateral bending. It seems that a herniation requires an additional failure of the cartilaginous endplate, likely initiated by further axial compressive load.Level of Evidence: 4",
author = "Nikolaus Berger-Roscher and Gloria Casaroli and Volker Rasche and Tomaso Villa and Fabio Galbusera and Wilke, {Hans Joachim}",
year = "2017",
doi = "10.1097/BRS.0000000000001699",
language = "English",
volume = "42",
pages = "E78--E85",
journal = "Spine",
issn = "0362-2436",
publisher = "Lippincott Williams and Wilkins",
number = "2",

}

TY - JOUR

T1 - Influence of Complex Loading Conditions on Intervertebral Disc Failure

AU - Berger-Roscher, Nikolaus

AU - Casaroli, Gloria

AU - Rasche, Volker

AU - Villa, Tomaso

AU - Galbusera, Fabio

AU - Wilke, Hans Joachim

PY - 2017

Y1 - 2017

N2 - STUDY DESIGN.: High resolution imaging investigation of the failure of ovine lumbar intervertebral discs under complex loading. OBJECTIVE.: To investigate how different loading combinations influence the mechanism and extent of intervertebral disc failure. SUMMARY OF BACKGROUND DATA.: Even though there has been extensive research on how an intervertebral disc fails under various conditions, failure mechanisms remain unclear. In addition, the influence of different loading directions on the mode and extent of failure under complex loading was never systematically investigated. METHODS.: Thirty ovine lumbar spinal segments were loaded in a newly developed, dynamic, 6-DOF disc loading simulator under five combinations of the following loading parameters: 0°-13° flexion, 0°-10° lateral bending, 0°-4° axial rotation, 0 N-800?N axial compression. A total of 1,000 cycles at 2?Hz were done. After testing, imaging of the discs was performed in an ultra-high field MRI (11.7 T) scanner as well as with a μCT scanner. RESULTS.: A total of 13 large endplate junction failures (EPJFs) occurred, of which all but one maintained an intact cartilaginous endplate. 10 out of 13 EPJFs occurred caudally. Four solely annulus failures occurred affecting only the outer posterior annulus. A herniation was not observed. The maximum moments measured in any group (median) were 52.5 Nm flexion, 16.5 Nm lateral bending, and 14.0 Nm axial rotation. CONCLUSIONS.: Complex loading protocols could lead to EPJFs (76%) as well as annulus failures (24%) in vitro. The combination of flexion, lateral bending, axial rotation, and axial compression bears the highest risk for caudal EPJF. Flexion without lateral bending and vice versa has the lowest risk for failure. Both axial compression and axial rotation seem to have a smaller influence than flexion and lateral bending. It seems that a herniation requires an additional failure of the cartilaginous endplate, likely initiated by further axial compressive load.Level of Evidence: 4

AB - STUDY DESIGN.: High resolution imaging investigation of the failure of ovine lumbar intervertebral discs under complex loading. OBJECTIVE.: To investigate how different loading combinations influence the mechanism and extent of intervertebral disc failure. SUMMARY OF BACKGROUND DATA.: Even though there has been extensive research on how an intervertebral disc fails under various conditions, failure mechanisms remain unclear. In addition, the influence of different loading directions on the mode and extent of failure under complex loading was never systematically investigated. METHODS.: Thirty ovine lumbar spinal segments were loaded in a newly developed, dynamic, 6-DOF disc loading simulator under five combinations of the following loading parameters: 0°-13° flexion, 0°-10° lateral bending, 0°-4° axial rotation, 0 N-800?N axial compression. A total of 1,000 cycles at 2?Hz were done. After testing, imaging of the discs was performed in an ultra-high field MRI (11.7 T) scanner as well as with a μCT scanner. RESULTS.: A total of 13 large endplate junction failures (EPJFs) occurred, of which all but one maintained an intact cartilaginous endplate. 10 out of 13 EPJFs occurred caudally. Four solely annulus failures occurred affecting only the outer posterior annulus. A herniation was not observed. The maximum moments measured in any group (median) were 52.5 Nm flexion, 16.5 Nm lateral bending, and 14.0 Nm axial rotation. CONCLUSIONS.: Complex loading protocols could lead to EPJFs (76%) as well as annulus failures (24%) in vitro. The combination of flexion, lateral bending, axial rotation, and axial compression bears the highest risk for caudal EPJF. Flexion without lateral bending and vice versa has the lowest risk for failure. Both axial compression and axial rotation seem to have a smaller influence than flexion and lateral bending. It seems that a herniation requires an additional failure of the cartilaginous endplate, likely initiated by further axial compressive load.Level of Evidence: 4

UR - http://www.scopus.com/inward/record.url?scp=84969256288&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84969256288&partnerID=8YFLogxK

U2 - 10.1097/BRS.0000000000001699

DO - 10.1097/BRS.0000000000001699

M3 - Article

AN - SCOPUS:84969256288

VL - 42

SP - E78-E85

JO - Spine

JF - Spine

SN - 0362-2436

IS - 2

ER -