Influence of different glycosphingolipids on the conductometric properties of a model phospholipid membrane system

C. Cametti, F. De Luca, M. A. Macrì, B. Maraviglia, R. Misasi, M. Sorice, A. Pavan, T. Garofalo, G. M. Pontieri, F. Bordi, G. Zimatore

Research output: Contribution to journalArticlepeer-review

Abstract

The conductometric properties of aqueous solutions of liposomes built up by inserting different gangliosides at different concentrations in a phospholipid bilayer have been investigated in the radio frequency region, where the alteration of the electrical surface polarization produced in the membrane structure by the ganglioside insertion can be properly observed. We have studied a series of gangliosides (GM1, GM2, GM3, GD1a, GD1b, aGM1) characterized by the same hydrophobic part but with different hydrophilic portions. The results show a quite complex conductivity behaviour that can be only partially accounted for in terms of a surface conductance contribution. Some phenomenological correlations between the hydrophilic head group structure and the electrical conductivity behaviour are presented.

Original languageEnglish
Pages (from-to)39-46
Number of pages8
JournalColloids and Surfaces B: Biointerfaces
Volume7
Issue number1-2
DOIs
Publication statusPublished - Jul 31 1996

Keywords

  • Conductometric properties
  • Gangliosides
  • Liposomes
  • Phospholipid membrane

ASJC Scopus subject areas

  • Biotechnology
  • Colloid and Surface Chemistry
  • Physical and Theoretical Chemistry
  • Surfaces and Interfaces

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