Influence of different implant surfaces on peri-implant osteogenesis: Histomorphometric analysis in sheep

Marco Franchi, Beatrice Bacchelli, Gianluca Giavaresi, Viviana De Pasquale, Désirée Martini, Milena Fini, Roberto Giardino, Alessandro Ruggeri

Research output: Contribution to journalArticlepeer-review


Background: The presents study investigated peri-implant osteogenesis and implant biologic fixation in different zirconia sandblasted endosseous titanium surfaces (SLA-60 and SLA-120) and a turned titanium surface (T) 2 and 4 weeks after surgery. Methods: Seventy-two implant s crews were implanted in tibia of six sheep. Histologic sections of implants (2 and 4 weeks after surgery) were analyzed with light microscopy for histomorphometric analysis of bone-to-implant contact (BIC), bone ingrowth (BI), and bone surface (BS/ BV). Histologic blocks were used to perform bone microhardness studies next to the implants. Some implants were also observed with scanning electron microscopy (SEM) and transmission electron microscopy (TEM). R esults: In general, the highest values of BIC, BI, BS/BV, and Vickers hardness number (HV) were measured in SLA-60 samples, followed by SLA-120 and T implants. Two weeks after surgery, all the implants appeared biologically fixed by a newly formed woven bone arranged in thin bone trabeculae and filling the gap between implant and host bone. Four weeks after implantation, the thickness of the woven bone trabeculae had increased, especially around the SLA-60 and SLA-120 implants by a gradual deposition of parallel-fiber bone. Conclusions: O ur results suggest that, in the early period of peri-implant healing, the implant surface morphology that seemed to influence the increase of peri-implant osteogenesis, bone turnover, and peri-implant bone maturation was SLA-60. We suggest that this surface, characterized by moderately deep titanium cavities very similar to the osteocyte lacunae, could act as a microscopic s scaffold for mesenchymal and/or osteoblast-like cells adhesion.

Original languageEnglish
Pages (from-to)879-888
Number of pages10
JournalJournal of Periodontology
Issue number5
Publication statusPublished - May 2007


  • Dental implantation
  • Electron
  • Endosseous
  • Histology
  • Microscopy
  • Osseointegration
  • Titanium
  • Zirconium oxide

ASJC Scopus subject areas

  • Dentistry(all)


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