TY - JOUR
T1 - Influence of different lipid emulsions on specific immune cell functions in head and neck cancer patients receiving supplemental parenteral nutrition
T2 - An exploratory analysis
AU - Candiloro, Francesca
AU - Borioli, Valeria
AU - Borsellino, Giovanna
AU - Picozza, Mario
AU - Pellini, Raul
AU - Cereda, Emanuele
AU - Gargano, Francesca
AU - Caraccia, Marilisa
AU - Nardi, Maria Teresa
AU - Bellu, Luisa
AU - Tondulli, Luca
AU - Imarisio, Ilaria
AU - Pozzi, Emma
AU - Pedrazzoli, Paolo
AU - Caccialanza, Riccardo
AU - Battistini, Luca
N1 - Publisher Copyright:
© 2021 The Authors
Copyright:
Copyright 2021 Elsevier B.V., All rights reserved.
PY - 2021/6
Y1 - 2021/6
N2 - Objectives: The effect of diet on immune responses is an area of intense investigation. Dietary lipids have been shown to differently influence and fine-tune the reactivity of immune cell subsets, thus potentially affecting clinical outcomes. Patients with head and neck squamous cell carcinoma face malnutrition, due to swallowing impairment related to the tumor site or to treatment sequalae, and may need supplemental parenteral nutrition (SPN) in addition to oral feeding when enteral nutrition is not feasible. Additionally, immune depression is a well-known complication in these patients. Parenteral nutrition (PN) bags contain amino acids, minerals, electrolytes and mostly lipids that provide calories in a concentrated form and are enriched with essential fatty acids. The aim of this study was to investigate multiple parameters of the immune responses in a cohort of patients with head and neck squamous cell carcinoma undergoing supplemental PN with bags enriched in ω-3 or ω-9 and ω-6 fatty acids. Methods: To our knowledge, this was the first exploratory study to investigate the effects of two different PN lipid emulsions on specific immune cells function of patients with advanced head and neck squamous carcinoma. ω-3-enriched fish-oil-based- and ω-6- and ω-9-enriched olive-oil-basedSPN was administered to two groups of patients for 1 wk in the context of an observational multicentric study. Polychromatic flow cytometry was used to investigate multiple subsets of leukocytes, with a special focus on cellular populations endowed with antitumor activity. Results: Patients treated with olive-oil-based PN showed an increase in the function of the innate (natural killer cells and monocytes) and adaptive (both CD4 and CD8 cells) arms of the immune response. Conclusion: An increase in the function of the innate and adaptive arms of the immune response may favor antitumoral responses.
AB - Objectives: The effect of diet on immune responses is an area of intense investigation. Dietary lipids have been shown to differently influence and fine-tune the reactivity of immune cell subsets, thus potentially affecting clinical outcomes. Patients with head and neck squamous cell carcinoma face malnutrition, due to swallowing impairment related to the tumor site or to treatment sequalae, and may need supplemental parenteral nutrition (SPN) in addition to oral feeding when enteral nutrition is not feasible. Additionally, immune depression is a well-known complication in these patients. Parenteral nutrition (PN) bags contain amino acids, minerals, electrolytes and mostly lipids that provide calories in a concentrated form and are enriched with essential fatty acids. The aim of this study was to investigate multiple parameters of the immune responses in a cohort of patients with head and neck squamous cell carcinoma undergoing supplemental PN with bags enriched in ω-3 or ω-9 and ω-6 fatty acids. Methods: To our knowledge, this was the first exploratory study to investigate the effects of two different PN lipid emulsions on specific immune cells function of patients with advanced head and neck squamous carcinoma. ω-3-enriched fish-oil-based- and ω-6- and ω-9-enriched olive-oil-basedSPN was administered to two groups of patients for 1 wk in the context of an observational multicentric study. Polychromatic flow cytometry was used to investigate multiple subsets of leukocytes, with a special focus on cellular populations endowed with antitumor activity. Results: Patients treated with olive-oil-based PN showed an increase in the function of the innate (natural killer cells and monocytes) and adaptive (both CD4 and CD8 cells) arms of the immune response. Conclusion: An increase in the function of the innate and adaptive arms of the immune response may favor antitumoral responses.
KW - Fatty acids
KW - Fish oil
KW - Head and neck squamous cell carcinoma
KW - Immune response
KW - Olive oil
KW - Parenteral nutrition
UR - http://www.scopus.com/inward/record.url?scp=85101351292&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85101351292&partnerID=8YFLogxK
U2 - 10.1016/j.nut.2021.111178
DO - 10.1016/j.nut.2021.111178
M3 - Article
AN - SCOPUS:85101351292
VL - 86
JO - Nutrition International
JF - Nutrition International
SN - 0899-9007
M1 - 111178
ER -