Influence of digitalis on left ventricular functional response to exercise in congestive heart failure

C. Morisco, A. Cuocolo, M. Romano, A. Nappi, G. Iaccarino, M. Volpe, M. Salvatore, B. Trimarco

Research output: Contribution to journalArticlepeer-review

Abstract

This was a double-blind, placebo-controlled, crossover study designed to determine the influence of digitalis treatment on left ventricular (LV) response to physical exercise in patients with congestive heart failure (CHF). In 10 patients with CHF (ejection fraction 29 ± 2%), LV function was assessed during upright bicycle exercise using an ambulatory radionuclide detector for continuous noninvasive monitoring of cardiac function. Exercise was performed during control conditions and after a 3-week treatment with digoxin (0.25 mg/day orally) or placebo. Ten normal volunteers matched for sex and age constituted the control group. In normals, exercise ejection fraction and end-diastolic volume increased (both p

Original languageEnglish
Pages (from-to)480-485
Number of pages6
JournalThe American Journal of Cardiology
Volume77
Issue number7
DOIs
Publication statusPublished - 1996

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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