Influence of enzyme inducing antiepileptic drugs on the pharmacokinetics of levetiracetam in patients with epilepsy

Priscila Freitas-Lima, Veriano Alexandre, Leonardo Regis Leira Pereira, Fausto Feletti, Emilio Perucca, Americo Ceiki Sakamoto

Research output: Contribution to journalArticle

Abstract

To assess whether levetiracetam elimination is influenced by enzyme inducing antiepileptic drugs (EIAEDs), serum levetiracetam levels were determined at frequent intervals after a single oral 1000. mg dose in 15 subjects co-medicated with EIAEDs and 15 matched controls. The EIAED group showed a higher levetiracetam oral clearance (p=0.01) and a shorter half-life (p=0.02) than controls. Although the magnitude of interaction is relatively modest, it could have clinical significance for some patients.

Original languageEnglish
Pages (from-to)117-120
Number of pages4
JournalEpilepsy Research
Volume94
Issue number1-2
DOIs
Publication statusPublished - Mar 2011

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etiracetam
Anticonvulsants
Epilepsy
Pharmacokinetics
Enzymes
Half-Life
Serum

Keywords

  • Drug interaction
  • Enzyme induction
  • Epilepsy
  • Levetiracetam
  • Pharmacokinetics

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

Cite this

Influence of enzyme inducing antiepileptic drugs on the pharmacokinetics of levetiracetam in patients with epilepsy. / Freitas-Lima, Priscila; Alexandre, Veriano; Pereira, Leonardo Regis Leira; Feletti, Fausto; Perucca, Emilio; Sakamoto, Americo Ceiki.

In: Epilepsy Research, Vol. 94, No. 1-2, 03.2011, p. 117-120.

Research output: Contribution to journalArticle

Freitas-Lima, Priscila ; Alexandre, Veriano ; Pereira, Leonardo Regis Leira ; Feletti, Fausto ; Perucca, Emilio ; Sakamoto, Americo Ceiki. / Influence of enzyme inducing antiepileptic drugs on the pharmacokinetics of levetiracetam in patients with epilepsy. In: Epilepsy Research. 2011 ; Vol. 94, No. 1-2. pp. 117-120.
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