Abstract
To assess whether levetiracetam elimination is influenced by enzyme inducing antiepileptic drugs (EIAEDs), serum levetiracetam levels were determined at frequent intervals after a single oral 1000. mg dose in 15 subjects co-medicated with EIAEDs and 15 matched controls. The EIAED group showed a higher levetiracetam oral clearance (p=0.01) and a shorter half-life (p=0.02) than controls. Although the magnitude of interaction is relatively modest, it could have clinical significance for some patients.
| Original language | English |
|---|---|
| Pages (from-to) | 117-120 |
| Number of pages | 4 |
| Journal | Epilepsy Research |
| Volume | 94 |
| Issue number | 1-2 |
| DOIs | |
| Publication status | Published - Mar 2011 |
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Keywords
- Drug interaction
- Enzyme induction
- Epilepsy
- Levetiracetam
- Pharmacokinetics
ASJC Scopus subject areas
- Clinical Neurology
- Neurology
Cite this
Influence of enzyme inducing antiepileptic drugs on the pharmacokinetics of levetiracetam in patients with epilepsy. / Freitas-Lima, Priscila; Alexandre, Veriano; Pereira, Leonardo Regis Leira; Feletti, Fausto; Perucca, Emilio; Sakamoto, Americo Ceiki.
In: Epilepsy Research, Vol. 94, No. 1-2, 03.2011, p. 117-120.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Influence of enzyme inducing antiepileptic drugs on the pharmacokinetics of levetiracetam in patients with epilepsy
AU - Freitas-Lima, Priscila
AU - Alexandre, Veriano
AU - Pereira, Leonardo Regis Leira
AU - Feletti, Fausto
AU - Perucca, Emilio
AU - Sakamoto, Americo Ceiki
PY - 2011/3
Y1 - 2011/3
N2 - To assess whether levetiracetam elimination is influenced by enzyme inducing antiepileptic drugs (EIAEDs), serum levetiracetam levels were determined at frequent intervals after a single oral 1000. mg dose in 15 subjects co-medicated with EIAEDs and 15 matched controls. The EIAED group showed a higher levetiracetam oral clearance (p=0.01) and a shorter half-life (p=0.02) than controls. Although the magnitude of interaction is relatively modest, it could have clinical significance for some patients.
AB - To assess whether levetiracetam elimination is influenced by enzyme inducing antiepileptic drugs (EIAEDs), serum levetiracetam levels were determined at frequent intervals after a single oral 1000. mg dose in 15 subjects co-medicated with EIAEDs and 15 matched controls. The EIAED group showed a higher levetiracetam oral clearance (p=0.01) and a shorter half-life (p=0.02) than controls. Although the magnitude of interaction is relatively modest, it could have clinical significance for some patients.
KW - Drug interaction
KW - Enzyme induction
KW - Epilepsy
KW - Levetiracetam
KW - Pharmacokinetics
UR - http://www.scopus.com/inward/record.url?scp=79952439180&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=79952439180&partnerID=8YFLogxK
U2 - 10.1016/j.eplepsyres.2011.01.007
DO - 10.1016/j.eplepsyres.2011.01.007
M3 - Article
C2 - 21282041
AN - SCOPUS:79952439180
VL - 94
SP - 117
EP - 120
JO - Epilepsy Research
JF - Epilepsy Research
SN - 0920-1211
IS - 1-2
ER -