Influence of Etiology of Heart Failure on the Obesity Paradox

Ross Arena, Jonathan Myers, Joshua Abella, Sherry Pinkstaff, Peter Brubaker, Brian Moore, Dalane Kitzman, Mary Ann Peberdy, Daniel Bensimhon, Paul Chase, Daniel Forman, Erin West, Marco Guazzi

Research output: Contribution to journalArticlepeer-review


Several investigations have demonstrated that higher body weight, as assessed by the body mass index, is associated with improved prognosis in patients with heart failure (HF). The purpose of the present investigation was to assess the influence of HF etiology on the prognostic ability of the body mass index in a cohort undergoing cardiopulmonary exercise testing. A total of 1,160 subjects were included in the analysis. All subjects underwent cardiopulmonary exercise testing, at which the minute ventilation/carbon dioxide production slope and peak oxygen consumption were determined. In the overall group, 193 cardiac deaths occurred during a mean follow-up of 30.7 ± 25.6 months (annual event rate 6.0%). The subjects classified as obese consistently had improved survival compared to those classified as normal weight (overall survival rate 88.0% vs ≤81.1%, p

Original languageEnglish
Pages (from-to)1116-1121
Number of pages6
JournalThe American Journal of Cardiology
Issue number8
Publication statusPublished - Oct 15 2009

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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