Influence of gangliosides on primary and metastatic neoplastic growth in human and murine cells

G. Alessandri, S. Filippeschi, P. Sinibaldi, F. Mornet, P. Passera, F. Spreafico, P. M. Cappa, P. M. Gullino

Research output: Contribution to journalArticle

Abstract

The influence of gangliosides on tumor growth and frequency of metastasis in vivo as well as on growth and motility of neoplastic cells in vitro was tested utilizing human and rodent cell populations. In mice receiving injections of a ganglioside mixture twice daily the tumor volume, the number of spontaneous metastases per animal, and the number of mice with metastasis was approximately double that of controls. Preincubation of neoplastic cells with the ganglioside mixture doubled the number of metastatic foci in the lungs of mice receiving the cells by i.v. injection. Addition of a ganglioside mixture to the culture medium enhanced motility of neoplastic cells about 3-fold. This finding was similar to that observed for capillary endothelium. The presence of gangliosides in the culture media for a 48-h incubation period about doubled the number of neoplastic cells as compared to controls; the same was observed for capillary endothelium. The data are interpreted to indicate that gangliosides improve growth and mobilization of capillary endothelium and neoplastic cells. Both events may concur in enhancing tumor growth in vivo, the first by improving angiogenesis, the second by direct action on the neoplastic cell population.

Original languageEnglish
Pages (from-to)4243-4247
Number of pages5
JournalCancer Research
Volume47
Issue number16
Publication statusPublished - 1987

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Gangliosides
Vascular Endothelium
Growth
Neoplasm Metastasis
Cell Movement
Culture Media
Injections
Tumor Burden
Population
Rodentia
Neoplasms
Cell Count
Lung

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Alessandri, G., Filippeschi, S., Sinibaldi, P., Mornet, F., Passera, P., Spreafico, F., ... Gullino, P. M. (1987). Influence of gangliosides on primary and metastatic neoplastic growth in human and murine cells. Cancer Research, 47(16), 4243-4247.

Influence of gangliosides on primary and metastatic neoplastic growth in human and murine cells. / Alessandri, G.; Filippeschi, S.; Sinibaldi, P.; Mornet, F.; Passera, P.; Spreafico, F.; Cappa, P. M.; Gullino, P. M.

In: Cancer Research, Vol. 47, No. 16, 1987, p. 4243-4247.

Research output: Contribution to journalArticle

Alessandri, G, Filippeschi, S, Sinibaldi, P, Mornet, F, Passera, P, Spreafico, F, Cappa, PM & Gullino, PM 1987, 'Influence of gangliosides on primary and metastatic neoplastic growth in human and murine cells', Cancer Research, vol. 47, no. 16, pp. 4243-4247.
Alessandri G, Filippeschi S, Sinibaldi P, Mornet F, Passera P, Spreafico F et al. Influence of gangliosides on primary and metastatic neoplastic growth in human and murine cells. Cancer Research. 1987;47(16):4243-4247.
Alessandri, G. ; Filippeschi, S. ; Sinibaldi, P. ; Mornet, F. ; Passera, P. ; Spreafico, F. ; Cappa, P. M. ; Gullino, P. M. / Influence of gangliosides on primary and metastatic neoplastic growth in human and murine cells. In: Cancer Research. 1987 ; Vol. 47, No. 16. pp. 4243-4247.
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