Influence of geolocation and ethnicity on the phenotypic expression of primary Sjögren's syndrome at diagnosis in 8310 patients: A cross-sectional study from the Big Data Sjögren Project Consortium

Pilar Brito-Zerón, Nihan Acar-Denizli, Margit Zeher, Astrid Rasmussen, Raphaele Seror, Elke Theander, Xiaomei Li, Chiara Baldini, Jacques Eric Gottenberg, Debashish Danda, Luca Quartuccio, Roberta Priori, Gabriela Hernandez-Molina, Aike A. Kruize, Valeria Valim, Marika Kvarnstrom, Damien Sene, Roberto Gerli, Sonja Praprotnik, David IsenbergRoser Solans, Maureen Rischmueller, Seung Ki Kwok, Gunnel Nordmark, Yasunori Suzuki, Roberto Giacomelli, Valerie Devauchelle-Pensec, Michele Bombardieri, Benedikt Hofauer, Hendrika Bootsma, Johan G. Brun, Guadalupe Fraile, Steven E. Carsons, Tamer A. Gheita, Jacques Morel, Cristina Vollenveider, Fabiola Atzeni, Soledad Retamozo, Ildiko Fanny Horvath, Kathy L. Sivils, Thomas Mandl, Pulukool Sandhya, Salvatore De Vita, Jorge Sanchez-Guerrero, Eefje van der Heijden, Virginia Fernandes Moça Trevisani, Marie Wahren-Herlenius, Xavier Mariette, Manuel Ramos-Casals

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

Objectives To analyse the influence of geolocation and ethnicity on the clinical presentation of primary Sjögren's syndrome (SjS) at diagnosis. Methods The Big Data Sjögren Project Consortium is an international, multicentre registry designed in 2014. By January 2016, 20 centres from five continents were participating. Multivariable logistic regression analyses were performed. Results We included 7748 women (93%) and 562 men (7%), with a mean age at diagnosis of primary SjS of 53 years. Ethnicity data were available for 7884 patients (95%): 6174 patients (78%) were white, 1066 patients (14%) were Asian, 393 patients (5%) were Hispanic, 104 patients (1%) were black/African- American and 147 patients (2%) were of other ethnicities. SjS was diagnosed a mean of 7 years earlier in black/African-American compared with white patients; the female-to-male ratio was highest in Asian patients (27:1) and lowest in black/African-American patients (7:1); the prevalence of sicca symptoms was lowest in Asian patients; a higher frequency of positive salivary biopsy was found in Hispanic and white patients. A north-south gradient was found with respect to a lower frequency of ocular involvement in northern countries for dry eyes and abnormal ocular tests in Europe (OR 0.46 and 0.44, respectively) and Asia (OR 0.18 and 0.49, respectively) compared with southern countries. Higher frequencies of antinuclear antibodies (ANAs) were reported in northern countries in America (OR=1.48) and Asia (OR=3.80) while, in Europe, northern countries had lowest frequencies of ANAs (OR=0.67) and Ro/La (OR=0.69). Conclusions This study provides the first evidence of a strong influence of geolocation and ethnicity on the phenotype of primary SjS at diagnosis.

Original languageEnglish
JournalAnnals of the Rheumatic Diseases
DOIs
Publication statusAccepted/In press - Nov 29 2016

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Cross-Sectional Studies
Antinuclear Antibodies
Biopsy
Logistics
African Americans
Hispanic Americans
Big data
Registries
Logistic Models
Regression Analysis
Phenotype

ASJC Scopus subject areas

  • Immunology and Allergy
  • Rheumatology
  • Immunology
  • Biochemistry, Genetics and Molecular Biology(all)

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Influence of geolocation and ethnicity on the phenotypic expression of primary Sjögren's syndrome at diagnosis in 8310 patients : A cross-sectional study from the Big Data Sjögren Project Consortium. / Brito-Zerón, Pilar; Acar-Denizli, Nihan; Zeher, Margit; Rasmussen, Astrid; Seror, Raphaele; Theander, Elke; Li, Xiaomei; Baldini, Chiara; Gottenberg, Jacques Eric; Danda, Debashish; Quartuccio, Luca; Priori, Roberta; Hernandez-Molina, Gabriela; Kruize, Aike A.; Valim, Valeria; Kvarnstrom, Marika; Sene, Damien; Gerli, Roberto; Praprotnik, Sonja; Isenberg, David; Solans, Roser; Rischmueller, Maureen; Kwok, Seung Ki; Nordmark, Gunnel; Suzuki, Yasunori; Giacomelli, Roberto; Devauchelle-Pensec, Valerie; Bombardieri, Michele; Hofauer, Benedikt; Bootsma, Hendrika; Brun, Johan G.; Fraile, Guadalupe; Carsons, Steven E.; Gheita, Tamer A.; Morel, Jacques; Vollenveider, Cristina; Atzeni, Fabiola; Retamozo, Soledad; Horvath, Ildiko Fanny; Sivils, Kathy L.; Mandl, Thomas; Sandhya, Pulukool; Vita, Salvatore De; Sanchez-Guerrero, Jorge; van der Heijden, Eefje; Moça Trevisani, Virginia Fernandes; Wahren-Herlenius, Marie; Mariette, Xavier; Ramos-Casals, Manuel.

In: Annals of the Rheumatic Diseases, 29.11.2016.

Research output: Contribution to journalArticle

Brito-Zerón, P, Acar-Denizli, N, Zeher, M, Rasmussen, A, Seror, R, Theander, E, Li, X, Baldini, C, Gottenberg, JE, Danda, D, Quartuccio, L, Priori, R, Hernandez-Molina, G, Kruize, AA, Valim, V, Kvarnstrom, M, Sene, D, Gerli, R, Praprotnik, S, Isenberg, D, Solans, R, Rischmueller, M, Kwok, SK, Nordmark, G, Suzuki, Y, Giacomelli, R, Devauchelle-Pensec, V, Bombardieri, M, Hofauer, B, Bootsma, H, Brun, JG, Fraile, G, Carsons, SE, Gheita, TA, Morel, J, Vollenveider, C, Atzeni, F, Retamozo, S, Horvath, IF, Sivils, KL, Mandl, T, Sandhya, P, Vita, SD, Sanchez-Guerrero, J, van der Heijden, E, Moça Trevisani, VF, Wahren-Herlenius, M, Mariette, X & Ramos-Casals, M 2016, 'Influence of geolocation and ethnicity on the phenotypic expression of primary Sjögren's syndrome at diagnosis in 8310 patients: A cross-sectional study from the Big Data Sjögren Project Consortium', Annals of the Rheumatic Diseases. https://doi.org/10.1136/annrheumdis-2016-209952
Brito-Zerón, Pilar ; Acar-Denizli, Nihan ; Zeher, Margit ; Rasmussen, Astrid ; Seror, Raphaele ; Theander, Elke ; Li, Xiaomei ; Baldini, Chiara ; Gottenberg, Jacques Eric ; Danda, Debashish ; Quartuccio, Luca ; Priori, Roberta ; Hernandez-Molina, Gabriela ; Kruize, Aike A. ; Valim, Valeria ; Kvarnstrom, Marika ; Sene, Damien ; Gerli, Roberto ; Praprotnik, Sonja ; Isenberg, David ; Solans, Roser ; Rischmueller, Maureen ; Kwok, Seung Ki ; Nordmark, Gunnel ; Suzuki, Yasunori ; Giacomelli, Roberto ; Devauchelle-Pensec, Valerie ; Bombardieri, Michele ; Hofauer, Benedikt ; Bootsma, Hendrika ; Brun, Johan G. ; Fraile, Guadalupe ; Carsons, Steven E. ; Gheita, Tamer A. ; Morel, Jacques ; Vollenveider, Cristina ; Atzeni, Fabiola ; Retamozo, Soledad ; Horvath, Ildiko Fanny ; Sivils, Kathy L. ; Mandl, Thomas ; Sandhya, Pulukool ; Vita, Salvatore De ; Sanchez-Guerrero, Jorge ; van der Heijden, Eefje ; Moça Trevisani, Virginia Fernandes ; Wahren-Herlenius, Marie ; Mariette, Xavier ; Ramos-Casals, Manuel. / Influence of geolocation and ethnicity on the phenotypic expression of primary Sjögren's syndrome at diagnosis in 8310 patients : A cross-sectional study from the Big Data Sjögren Project Consortium. In: Annals of the Rheumatic Diseases. 2016.
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abstract = "Objectives To analyse the influence of geolocation and ethnicity on the clinical presentation of primary Sj{\"o}gren's syndrome (SjS) at diagnosis. Methods The Big Data Sj{\"o}gren Project Consortium is an international, multicentre registry designed in 2014. By January 2016, 20 centres from five continents were participating. Multivariable logistic regression analyses were performed. Results We included 7748 women (93{\%}) and 562 men (7{\%}), with a mean age at diagnosis of primary SjS of 53 years. Ethnicity data were available for 7884 patients (95{\%}): 6174 patients (78{\%}) were white, 1066 patients (14{\%}) were Asian, 393 patients (5{\%}) were Hispanic, 104 patients (1{\%}) were black/African- American and 147 patients (2{\%}) were of other ethnicities. SjS was diagnosed a mean of 7 years earlier in black/African-American compared with white patients; the female-to-male ratio was highest in Asian patients (27:1) and lowest in black/African-American patients (7:1); the prevalence of sicca symptoms was lowest in Asian patients; a higher frequency of positive salivary biopsy was found in Hispanic and white patients. A north-south gradient was found with respect to a lower frequency of ocular involvement in northern countries for dry eyes and abnormal ocular tests in Europe (OR 0.46 and 0.44, respectively) and Asia (OR 0.18 and 0.49, respectively) compared with southern countries. Higher frequencies of antinuclear antibodies (ANAs) were reported in northern countries in America (OR=1.48) and Asia (OR=3.80) while, in Europe, northern countries had lowest frequencies of ANAs (OR=0.67) and Ro/La (OR=0.69). Conclusions This study provides the first evidence of a strong influence of geolocation and ethnicity on the phenotype of primary SjS at diagnosis.",
author = "Pilar Brito-Zer{\'o}n and Nihan Acar-Denizli and Margit Zeher and Astrid Rasmussen and Raphaele Seror and Elke Theander and Xiaomei Li and Chiara Baldini and Gottenberg, {Jacques Eric} and Debashish Danda and Luca Quartuccio and Roberta Priori and Gabriela Hernandez-Molina and Kruize, {Aike A.} and Valeria Valim and Marika Kvarnstrom and Damien Sene and Roberto Gerli and Sonja Praprotnik and David Isenberg and Roser Solans and Maureen Rischmueller and Kwok, {Seung Ki} and Gunnel Nordmark and Yasunori Suzuki and Roberto Giacomelli and Valerie Devauchelle-Pensec and Michele Bombardieri and Benedikt Hofauer and Hendrika Bootsma and Brun, {Johan G.} and Guadalupe Fraile and Carsons, {Steven E.} and Gheita, {Tamer A.} and Jacques Morel and Cristina Vollenveider and Fabiola Atzeni and Soledad Retamozo and Horvath, {Ildiko Fanny} and Sivils, {Kathy L.} and Thomas Mandl and Pulukool Sandhya and Vita, {Salvatore De} and Jorge Sanchez-Guerrero and {van der Heijden}, Eefje and {Mo{\cc}a Trevisani}, {Virginia Fernandes} and Marie Wahren-Herlenius and Xavier Mariette and Manuel Ramos-Casals",
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day = "29",
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TY - JOUR

T1 - Influence of geolocation and ethnicity on the phenotypic expression of primary Sjögren's syndrome at diagnosis in 8310 patients

T2 - A cross-sectional study from the Big Data Sjögren Project Consortium

AU - Brito-Zerón, Pilar

AU - Acar-Denizli, Nihan

AU - Zeher, Margit

AU - Rasmussen, Astrid

AU - Seror, Raphaele

AU - Theander, Elke

AU - Li, Xiaomei

AU - Baldini, Chiara

AU - Gottenberg, Jacques Eric

AU - Danda, Debashish

AU - Quartuccio, Luca

AU - Priori, Roberta

AU - Hernandez-Molina, Gabriela

AU - Kruize, Aike A.

AU - Valim, Valeria

AU - Kvarnstrom, Marika

AU - Sene, Damien

AU - Gerli, Roberto

AU - Praprotnik, Sonja

AU - Isenberg, David

AU - Solans, Roser

AU - Rischmueller, Maureen

AU - Kwok, Seung Ki

AU - Nordmark, Gunnel

AU - Suzuki, Yasunori

AU - Giacomelli, Roberto

AU - Devauchelle-Pensec, Valerie

AU - Bombardieri, Michele

AU - Hofauer, Benedikt

AU - Bootsma, Hendrika

AU - Brun, Johan G.

AU - Fraile, Guadalupe

AU - Carsons, Steven E.

AU - Gheita, Tamer A.

AU - Morel, Jacques

AU - Vollenveider, Cristina

AU - Atzeni, Fabiola

AU - Retamozo, Soledad

AU - Horvath, Ildiko Fanny

AU - Sivils, Kathy L.

AU - Mandl, Thomas

AU - Sandhya, Pulukool

AU - Vita, Salvatore De

AU - Sanchez-Guerrero, Jorge

AU - van der Heijden, Eefje

AU - Moça Trevisani, Virginia Fernandes

AU - Wahren-Herlenius, Marie

AU - Mariette, Xavier

AU - Ramos-Casals, Manuel

PY - 2016/11/29

Y1 - 2016/11/29

N2 - Objectives To analyse the influence of geolocation and ethnicity on the clinical presentation of primary Sjögren's syndrome (SjS) at diagnosis. Methods The Big Data Sjögren Project Consortium is an international, multicentre registry designed in 2014. By January 2016, 20 centres from five continents were participating. Multivariable logistic regression analyses were performed. Results We included 7748 women (93%) and 562 men (7%), with a mean age at diagnosis of primary SjS of 53 years. Ethnicity data were available for 7884 patients (95%): 6174 patients (78%) were white, 1066 patients (14%) were Asian, 393 patients (5%) were Hispanic, 104 patients (1%) were black/African- American and 147 patients (2%) were of other ethnicities. SjS was diagnosed a mean of 7 years earlier in black/African-American compared with white patients; the female-to-male ratio was highest in Asian patients (27:1) and lowest in black/African-American patients (7:1); the prevalence of sicca symptoms was lowest in Asian patients; a higher frequency of positive salivary biopsy was found in Hispanic and white patients. A north-south gradient was found with respect to a lower frequency of ocular involvement in northern countries for dry eyes and abnormal ocular tests in Europe (OR 0.46 and 0.44, respectively) and Asia (OR 0.18 and 0.49, respectively) compared with southern countries. Higher frequencies of antinuclear antibodies (ANAs) were reported in northern countries in America (OR=1.48) and Asia (OR=3.80) while, in Europe, northern countries had lowest frequencies of ANAs (OR=0.67) and Ro/La (OR=0.69). Conclusions This study provides the first evidence of a strong influence of geolocation and ethnicity on the phenotype of primary SjS at diagnosis.

AB - Objectives To analyse the influence of geolocation and ethnicity on the clinical presentation of primary Sjögren's syndrome (SjS) at diagnosis. Methods The Big Data Sjögren Project Consortium is an international, multicentre registry designed in 2014. By January 2016, 20 centres from five continents were participating. Multivariable logistic regression analyses were performed. Results We included 7748 women (93%) and 562 men (7%), with a mean age at diagnosis of primary SjS of 53 years. Ethnicity data were available for 7884 patients (95%): 6174 patients (78%) were white, 1066 patients (14%) were Asian, 393 patients (5%) were Hispanic, 104 patients (1%) were black/African- American and 147 patients (2%) were of other ethnicities. SjS was diagnosed a mean of 7 years earlier in black/African-American compared with white patients; the female-to-male ratio was highest in Asian patients (27:1) and lowest in black/African-American patients (7:1); the prevalence of sicca symptoms was lowest in Asian patients; a higher frequency of positive salivary biopsy was found in Hispanic and white patients. A north-south gradient was found with respect to a lower frequency of ocular involvement in northern countries for dry eyes and abnormal ocular tests in Europe (OR 0.46 and 0.44, respectively) and Asia (OR 0.18 and 0.49, respectively) compared with southern countries. Higher frequencies of antinuclear antibodies (ANAs) were reported in northern countries in America (OR=1.48) and Asia (OR=3.80) while, in Europe, northern countries had lowest frequencies of ANAs (OR=0.67) and Ro/La (OR=0.69). Conclusions This study provides the first evidence of a strong influence of geolocation and ethnicity on the phenotype of primary SjS at diagnosis.

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DO - 10.1136/annrheumdis-2016-209952

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