Influence of glutaraldehyde on drug release and mucoadhesive properties of chitosan microspheres

Ida Genta, Monica Costantini, Annalia Asti, Bice Conti, Luisa Montanari

Research output: Contribution to journalArticle

Abstract

Among bioadhesive drug delivery systems, chitosan microspheres can be considered useful formulations for mucosal administration of drugs. The feasibility of modulating drug release from chitosan microparticles is due to polymer cross-linking, i.e. by glutaraldehyde. The aim of this work was to develop a new simple 'in vitro' technique based on electron microscopy in order to study the effect of polymer cross-linking density on mucoadhesive properties of the chitosan microspheres. This technique consists of scanning electron microscopy (SEM) and transmission electron microscopy (TEM) observations on morphological changes of chitosan microspheres with various cross-linking densities in contact with mucin solution. The results of SEM and TEM analyses have permitted to confirm the high affinity for mucin of uncross-linked chitosan microspheres and thus their bioadhesive properties. Moreover, bioadhesive characteristics of the microparticulate drug delivery systems were depressed for glutaraldehyde cross-linked chitosan microspheres.

Original languageEnglish
Pages (from-to)81-88
Number of pages8
JournalCarbohydrate Polymers
Volume36
Issue number2-3
Publication statusPublished - Jul 1998

Fingerprint

glutaraldehyde
Chitosan
Glutaral
chitosan
Microspheres
drugs
crosslinking
Pharmaceutical Preparations
drug delivery systems
mucins
Mucins
Drug Delivery Systems
Transmission Electron Microscopy
Electron Scanning Microscopy
transmission electron microscopy
polymers
Polymers
Mucosal Administration
scanning electron microscopy
Transmission electron microscopy

Keywords

  • Chitosan
  • Glutaraldehyde
  • Microspheres
  • Mucoadhesiveness

ASJC Scopus subject areas

  • Food Science
  • Biochemistry

Cite this

Genta, I., Costantini, M., Asti, A., Conti, B., & Montanari, L. (1998). Influence of glutaraldehyde on drug release and mucoadhesive properties of chitosan microspheres. Carbohydrate Polymers, 36(2-3), 81-88.

Influence of glutaraldehyde on drug release and mucoadhesive properties of chitosan microspheres. / Genta, Ida; Costantini, Monica; Asti, Annalia; Conti, Bice; Montanari, Luisa.

In: Carbohydrate Polymers, Vol. 36, No. 2-3, 07.1998, p. 81-88.

Research output: Contribution to journalArticle

Genta, I, Costantini, M, Asti, A, Conti, B & Montanari, L 1998, 'Influence of glutaraldehyde on drug release and mucoadhesive properties of chitosan microspheres', Carbohydrate Polymers, vol. 36, no. 2-3, pp. 81-88.
Genta I, Costantini M, Asti A, Conti B, Montanari L. Influence of glutaraldehyde on drug release and mucoadhesive properties of chitosan microspheres. Carbohydrate Polymers. 1998 Jul;36(2-3):81-88.
Genta, Ida ; Costantini, Monica ; Asti, Annalia ; Conti, Bice ; Montanari, Luisa. / Influence of glutaraldehyde on drug release and mucoadhesive properties of chitosan microspheres. In: Carbohydrate Polymers. 1998 ; Vol. 36, No. 2-3. pp. 81-88.
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