Abstract
In order to study whether different heart rates achieved at peak exercise by normal subjects and patients with coronary artery disease (CAD) affect the results of analysis of R-wave amplitude changes (ΔR), we evaluated ΔR at progressively increasing heart rate (HR) steps in 60 normal subjects with negative exercise tests (ET), in 130 patients with CAD, in 88 patients with true positive and 42 with false negative ET, and in 43 patients with no CAD and false positive ET. We found that the sensitivity and specificity of ΔR were HR dependent, the former decreasing and the latter increasing with progressively increasing HR steps. Mean values of ΔR did not discriminate among the four groups for HRs up to 150 bpm; significant differences were found between normal subjects and CAD patients, both with true positive and false negative stress tests, at HR > 150 bpm. False positive patients had mean ΔR similar to those found in normal subjects. We hypothesize that quantitative ΔR analysis could be useful in ECG diagnosis of false negative and false positive patients at HR > 150 bpm.
| Original language | English |
|---|---|
| Pages (from-to) | 61-68 |
| Number of pages | 8 |
| Journal | American Heart Journal |
| Volume | 107 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 1984 |
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ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
Cite this
Influence of heart rate on exercise-induced R-wave amplitude changes in coronary patients and normal subjects. / Caprio, Lorenzo de; Cuomo, Sergio; Vigorito, Carlo; Meccariello, Pasquale; Romano, Massimo; Zarra, Antonio M F; Rengo, Franco.
In: American Heart Journal, Vol. 107, No. 1, 1984, p. 61-68.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Influence of heart rate on exercise-induced R-wave amplitude changes in coronary patients and normal subjects
AU - Caprio, Lorenzo de
AU - Cuomo, Sergio
AU - Vigorito, Carlo
AU - Meccariello, Pasquale
AU - Romano, Massimo
AU - Zarra, Antonio M F
AU - Rengo, Franco
PY - 1984
Y1 - 1984
N2 - In order to study whether different heart rates achieved at peak exercise by normal subjects and patients with coronary artery disease (CAD) affect the results of analysis of R-wave amplitude changes (ΔR), we evaluated ΔR at progressively increasing heart rate (HR) steps in 60 normal subjects with negative exercise tests (ET), in 130 patients with CAD, in 88 patients with true positive and 42 with false negative ET, and in 43 patients with no CAD and false positive ET. We found that the sensitivity and specificity of ΔR were HR dependent, the former decreasing and the latter increasing with progressively increasing HR steps. Mean values of ΔR did not discriminate among the four groups for HRs up to 150 bpm; significant differences were found between normal subjects and CAD patients, both with true positive and false negative stress tests, at HR > 150 bpm. False positive patients had mean ΔR similar to those found in normal subjects. We hypothesize that quantitative ΔR analysis could be useful in ECG diagnosis of false negative and false positive patients at HR > 150 bpm.
AB - In order to study whether different heart rates achieved at peak exercise by normal subjects and patients with coronary artery disease (CAD) affect the results of analysis of R-wave amplitude changes (ΔR), we evaluated ΔR at progressively increasing heart rate (HR) steps in 60 normal subjects with negative exercise tests (ET), in 130 patients with CAD, in 88 patients with true positive and 42 with false negative ET, and in 43 patients with no CAD and false positive ET. We found that the sensitivity and specificity of ΔR were HR dependent, the former decreasing and the latter increasing with progressively increasing HR steps. Mean values of ΔR did not discriminate among the four groups for HRs up to 150 bpm; significant differences were found between normal subjects and CAD patients, both with true positive and false negative stress tests, at HR > 150 bpm. False positive patients had mean ΔR similar to those found in normal subjects. We hypothesize that quantitative ΔR analysis could be useful in ECG diagnosis of false negative and false positive patients at HR > 150 bpm.
UR - http://www.scopus.com/inward/record.url?scp=0021334239&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0021334239&partnerID=8YFLogxK
U2 - 10.1016/0002-8703(84)90134-0
DO - 10.1016/0002-8703(84)90134-0
M3 - Article
C2 - 6691241
AN - SCOPUS:0021334239
VL - 107
SP - 61
EP - 68
JO - American Heart Journal
JF - American Heart Journal
SN - 0002-8703
IS - 1
ER -