Influence of HLA-DQ2 and DQ8 on severity in celiac disease

Federico Biagi, Paola I. Bianchi, Claudia Vattiato, Alessandra Marchese, Lucia Trotta, Carla Badulli, Annalisa De Silvestri, Miryam Martinetti, Gino R. Corazza

Research output: Contribution to journalArticlepeer-review

Abstract

Background: HLA-DQB1 *02 homozygosity was shown to be more common in patients with complicated rather than uncomplicated celiac disease (CD). Goals: To study HLA-DQA1 and DQB1 profile in adult patients with different forms of CD, including patients with complicated and potential CD, the most affected and the most preserved histologic end of the pathologic celiac spectrum. Study: HLA-DQA1 and DQB1 molecular typing was performed in 218 adult CD patients (169 with uncomplicated CD, 27 with complicated CD, and 22 with potential CD) and 224 healthy stem cell donors. HLA-DQA1 and DQB1 gene polymorphism was analyzed using polymerase chain reaction sequence-specific primers and/or reverse polymerase chain reaction sequence-specific oligonucleotides techniques. Results: As expected, the frequency of HLA-DQB1 *02 allele, DQB1 *02 homozygosity, and DQB1 *0302 gene were statistically different in the 4 groups. However, multivariate analysis demonstrated that patients with potential CD have a higher frequency of both HLA-DQB1 *0302 and HLA-DQB1 *0603 alleles and a reduced frequency of DQB1 *02 homozygosity compared with patients with uncomplicated and complicated CD. Conclusions: The increased frequency of DQB1 *0302 and the reduced frequency of DQB1 *02 homozygosity in potential CD is consistent with the idea that different clinical/pathologic evolutions might be related to different immunogeneses. This could be clinically relevant in the future.

Original languageEnglish
Pages (from-to)46-50
Number of pages5
JournalJournal of Clinical Gastroenterology
Volume46
Issue number1
DOIs
Publication statusPublished - Jan 2012

Keywords

  • Celiac disease
  • Gliadin
  • HLA
  • Immunogenesis

ASJC Scopus subject areas

  • Gastroenterology

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