Influence of HLA-G polymorphisms in human immunodeficiency virus infection and hepatitis C virus co-infection in Brazilian and Italian individuals

G. K. da Silva, Priscila Vianna, Tiago Degani Veit, Sergio Crovella, Eulalia Catamo, Elvira Alicia Aparicio Cordero, Vanessa Suñé Mattevi, Rosmeri Kuhmmer Lazzaretti, Eduardo Sprinz, Regina Kuhmmer, José Artur Bogo Chies

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Abstract

Objective: This study aimed to investigate the role of Human Leukocyte Antigen (HLA)-G in the susceptibility to HIV-1 infection through the analysis of the HLA-G 3' untranslated region (UTR) polymorphisms 14. bp insertion/deletion (rs66554220) and +3142C>G (rs1063320). Design: We analyzed 582 HIV-1 infected patients and 626 uninfected individuals from Brazil and Italy in a case-control study. Methods: HLA-G polymorphisms were genotyped using PCR, PCR-RFLP assays or direct sequencing. All analyses were stratified by ethnicity. Genotypic, allelic and diplotypic frequencies were compared between HIV-1 infected subjects and controls using Chi-square or Fischer exact tests. Also, haplotypic frequencies were estimated using MLocus software. Results: African-derived HIV-infected individuals presented a higher frequency of the 14bp insertion allele as compared to non-infected individuals (0.468 versus 0.373, respectively; pBonf=0.010). A higher frequency of the 14bp insertion +3142G (insG) haplotype (0.456 versus 0.346, p

Original languageEnglish
Pages (from-to)418-423
Number of pages6
JournalInfection, Genetics and Evolution
Volume21
DOIs
Publication statusPublished - Jan 2014

Keywords

  • Ethnicity
  • HCV
  • HIV
  • HLA-G
  • Polymorphism

ASJC Scopus subject areas

  • Ecology, Evolution, Behavior and Systematics
  • Genetics
  • Molecular Biology
  • Microbiology
  • Infectious Diseases
  • Microbiology (medical)
  • Medicine(all)

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    da Silva, G. K., Vianna, P., Veit, T. D., Crovella, S., Catamo, E., Cordero, E. A. A., Mattevi, V. S., Lazzaretti, R. K., Sprinz, E., Kuhmmer, R., & Chies, J. A. B. (2014). Influence of HLA-G polymorphisms in human immunodeficiency virus infection and hepatitis C virus co-infection in Brazilian and Italian individuals. Infection, Genetics and Evolution, 21, 418-423. https://doi.org/10.1016/j.meegid.2013.12.013