Influence of hormonal and reproductive factors on the risk of vertebral deformity in European women

T. W. O'Neill, A. J. Silman, M. Naves Diaz, C. Cooper, J. Kanis, D. Felsenberg, D. Agnusdei, K. Bergmann, J. Dequeker, J. A. Kanis, G. Kruskemper, H. Raspe, J. Varlow, D. Marsden, E. Wieland, L. Kalidis, J. Mews, T. Lauermann, K. Weber, P. Geusens & 54 others I. Jajic, S. Havelka, P. Vavrincova, P. D. Delmas, F. Marchand, D. Banzer, S. Kirschner, W. Reisinger, J. Janott, H. Schatz, J. Franke, C. Scheidt-Nave, R. Ziegler, K. Abendroth, B. Felsch, C. Matthis, A. Antoniou, G. Lyritis, C. Kiss, G. Poor, C. Gennari, S. Ortolani, A. Hofman, H. A P Pols, J. A. Falch, H. E. Meyer, S. Czekalski, T. Miazgowski, K. Hoszowski, R. S. Lorenc, A. Aroso, A. Lopez Vaz, L. I. Benevolenskaya, E. E. Mikhailov, A. Letkovska, P. Masaryk, D. Roig Escofet, M. Ruiz Martin, M. Sosa, M. Diaz Curiel, A. Rapado, J. B. Cannata Andia, J. B. Diaz Lopez, O. Johnell, B. Nilsson, G. Dilsen, D. M. Reid, A. K. Bhalla, F. Ring, C. Todd, R. Williams, J. Reeve, R. Eastell, A. D. Woolf

Research output: Contribution to journalArticle

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Abstract

The aim of this study was to determine whether variation in the level of selected hormonal and reproductive variables might explain variation in the occurrence of vertebral deformity across Europe. A population-based cross-sectional survey method was used. A total of 7530 women aged 50-79 years and over were recruited from 30 European centres. Subjects were invited to attend for an interviewer-administered questionnaire and lateral spinal radiographs which were taken according to a standard protocol. After adjusting for age, centre, body mass index and smoking, those in the highest quintile of menarche (age ≤ 16 years) had an increased risk of vertebral deformity (odds ratio [OR] = 1.48; 95% confidence interval [CI] 1.16, 1.88). Increased menopausal age (> 52.5 years) was associated with a reduced risk of deformity (OR = 0.78; 95% CI 0.60, 1.00), while use of the oral contraceptive pill was also protective (OR 0.76; 95% CI 0.58, 0.99). There was a smaller protective effect associated with one or more years use of hormone replacement therapy, though the confidence limits clearly embraced unity. There was no apparent effect of parity or breast-feeding on the risk of deformity. We conclude that oestrogen status is an important determinant of vertebral deformity. Ever use of the oral contraceptive pill was associated with a 25% reduction in risk of deformity though the effect may be a result of the higher-dosage oestrogen pills used in the past. Parity and breast-feeding do not appear to be important and would appear to have little potential for identification of women at high risk of vertebral deformity.

Original languageEnglish
Pages (from-to)72-78
Number of pages7
JournalOsteoporosis International
Volume7
Issue number1
DOIs
Publication statusPublished - 1997

Fingerprint

Odds Ratio
Confidence Intervals
Oral Contraceptives
Parity
Breast Feeding
Estrogens
Menarche
Hormone Replacement Therapy
Risk Reduction Behavior
Body Mass Index
Cross-Sectional Studies
Smoking
Interviews
Population
Surveys and Questionnaires

Keywords

  • Menarche
  • Menopause
  • Oral contraceptive pill
  • Parity
  • Vertebral osteoporosis

ASJC Scopus subject areas

  • Medicine(all)

Cite this

O'Neill, T. W., Silman, A. J., Naves Diaz, M., Cooper, C., Kanis, J., Felsenberg, D., ... Woolf, A. D. (1997). Influence of hormonal and reproductive factors on the risk of vertebral deformity in European women. Osteoporosis International, 7(1), 72-78. https://doi.org/10.1007/BF01623464

Influence of hormonal and reproductive factors on the risk of vertebral deformity in European women. / O'Neill, T. W.; Silman, A. J.; Naves Diaz, M.; Cooper, C.; Kanis, J.; Felsenberg, D.; Agnusdei, D.; Bergmann, K.; Dequeker, J.; Kanis, J. A.; Kruskemper, G.; Raspe, H.; Varlow, J.; Marsden, D.; Wieland, E.; Kalidis, L.; Mews, J.; Lauermann, T.; Weber, K.; Geusens, P.; Jajic, I.; Havelka, S.; Vavrincova, P.; Delmas, P. D.; Marchand, F.; Banzer, D.; Kirschner, S.; Reisinger, W.; Janott, J.; Schatz, H.; Franke, J.; Scheidt-Nave, C.; Ziegler, R.; Abendroth, K.; Felsch, B.; Matthis, C.; Antoniou, A.; Lyritis, G.; Kiss, C.; Poor, G.; Gennari, C.; Ortolani, S.; Hofman, A.; Pols, H. A P; Falch, J. A.; Meyer, H. E.; Czekalski, S.; Miazgowski, T.; Hoszowski, K.; Lorenc, R. S.; Aroso, A.; Lopez Vaz, A.; Benevolenskaya, L. I.; Mikhailov, E. E.; Letkovska, A.; Masaryk, P.; Roig Escofet, D.; Ruiz Martin, M.; Sosa, M.; Diaz Curiel, M.; Rapado, A.; Cannata Andia, J. B.; Diaz Lopez, J. B.; Johnell, O.; Nilsson, B.; Dilsen, G.; Reid, D. M.; Bhalla, A. K.; Ring, F.; Todd, C.; Williams, R.; Reeve, J.; Eastell, R.; Woolf, A. D.

In: Osteoporosis International, Vol. 7, No. 1, 1997, p. 72-78.

Research output: Contribution to journalArticle

O'Neill, TW, Silman, AJ, Naves Diaz, M, Cooper, C, Kanis, J, Felsenberg, D, Agnusdei, D, Bergmann, K, Dequeker, J, Kanis, JA, Kruskemper, G, Raspe, H, Varlow, J, Marsden, D, Wieland, E, Kalidis, L, Mews, J, Lauermann, T, Weber, K, Geusens, P, Jajic, I, Havelka, S, Vavrincova, P, Delmas, PD, Marchand, F, Banzer, D, Kirschner, S, Reisinger, W, Janott, J, Schatz, H, Franke, J, Scheidt-Nave, C, Ziegler, R, Abendroth, K, Felsch, B, Matthis, C, Antoniou, A, Lyritis, G, Kiss, C, Poor, G, Gennari, C, Ortolani, S, Hofman, A, Pols, HAP, Falch, JA, Meyer, HE, Czekalski, S, Miazgowski, T, Hoszowski, K, Lorenc, RS, Aroso, A, Lopez Vaz, A, Benevolenskaya, LI, Mikhailov, EE, Letkovska, A, Masaryk, P, Roig Escofet, D, Ruiz Martin, M, Sosa, M, Diaz Curiel, M, Rapado, A, Cannata Andia, JB, Diaz Lopez, JB, Johnell, O, Nilsson, B, Dilsen, G, Reid, DM, Bhalla, AK, Ring, F, Todd, C, Williams, R, Reeve, J, Eastell, R & Woolf, AD 1997, 'Influence of hormonal and reproductive factors on the risk of vertebral deformity in European women', Osteoporosis International, vol. 7, no. 1, pp. 72-78. https://doi.org/10.1007/BF01623464
O'Neill, T. W. ; Silman, A. J. ; Naves Diaz, M. ; Cooper, C. ; Kanis, J. ; Felsenberg, D. ; Agnusdei, D. ; Bergmann, K. ; Dequeker, J. ; Kanis, J. A. ; Kruskemper, G. ; Raspe, H. ; Varlow, J. ; Marsden, D. ; Wieland, E. ; Kalidis, L. ; Mews, J. ; Lauermann, T. ; Weber, K. ; Geusens, P. ; Jajic, I. ; Havelka, S. ; Vavrincova, P. ; Delmas, P. D. ; Marchand, F. ; Banzer, D. ; Kirschner, S. ; Reisinger, W. ; Janott, J. ; Schatz, H. ; Franke, J. ; Scheidt-Nave, C. ; Ziegler, R. ; Abendroth, K. ; Felsch, B. ; Matthis, C. ; Antoniou, A. ; Lyritis, G. ; Kiss, C. ; Poor, G. ; Gennari, C. ; Ortolani, S. ; Hofman, A. ; Pols, H. A P ; Falch, J. A. ; Meyer, H. E. ; Czekalski, S. ; Miazgowski, T. ; Hoszowski, K. ; Lorenc, R. S. ; Aroso, A. ; Lopez Vaz, A. ; Benevolenskaya, L. I. ; Mikhailov, E. E. ; Letkovska, A. ; Masaryk, P. ; Roig Escofet, D. ; Ruiz Martin, M. ; Sosa, M. ; Diaz Curiel, M. ; Rapado, A. ; Cannata Andia, J. B. ; Diaz Lopez, J. B. ; Johnell, O. ; Nilsson, B. ; Dilsen, G. ; Reid, D. M. ; Bhalla, A. K. ; Ring, F. ; Todd, C. ; Williams, R. ; Reeve, J. ; Eastell, R. ; Woolf, A. D. / Influence of hormonal and reproductive factors on the risk of vertebral deformity in European women. In: Osteoporosis International. 1997 ; Vol. 7, No. 1. pp. 72-78.
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T1 - Influence of hormonal and reproductive factors on the risk of vertebral deformity in European women

AU - O'Neill, T. W.

AU - Silman, A. J.

AU - Naves Diaz, M.

AU - Cooper, C.

AU - Kanis, J.

AU - Felsenberg, D.

AU - Agnusdei, D.

AU - Bergmann, K.

AU - Dequeker, J.

AU - Kanis, J. A.

AU - Kruskemper, G.

AU - Raspe, H.

AU - Varlow, J.

AU - Marsden, D.

AU - Wieland, E.

AU - Kalidis, L.

AU - Mews, J.

AU - Lauermann, T.

AU - Weber, K.

AU - Geusens, P.

AU - Jajic, I.

AU - Havelka, S.

AU - Vavrincova, P.

AU - Delmas, P. D.

AU - Marchand, F.

AU - Banzer, D.

AU - Kirschner, S.

AU - Reisinger, W.

AU - Janott, J.

AU - Schatz, H.

AU - Franke, J.

AU - Scheidt-Nave, C.

AU - Ziegler, R.

AU - Abendroth, K.

AU - Felsch, B.

AU - Matthis, C.

AU - Antoniou, A.

AU - Lyritis, G.

AU - Kiss, C.

AU - Poor, G.

AU - Gennari, C.

AU - Ortolani, S.

AU - Hofman, A.

AU - Pols, H. A P

AU - Falch, J. A.

AU - Meyer, H. E.

AU - Czekalski, S.

AU - Miazgowski, T.

AU - Hoszowski, K.

AU - Lorenc, R. S.

AU - Aroso, A.

AU - Lopez Vaz, A.

AU - Benevolenskaya, L. I.

AU - Mikhailov, E. E.

AU - Letkovska, A.

AU - Masaryk, P.

AU - Roig Escofet, D.

AU - Ruiz Martin, M.

AU - Sosa, M.

AU - Diaz Curiel, M.

AU - Rapado, A.

AU - Cannata Andia, J. B.

AU - Diaz Lopez, J. B.

AU - Johnell, O.

AU - Nilsson, B.

AU - Dilsen, G.

AU - Reid, D. M.

AU - Bhalla, A. K.

AU - Ring, F.

AU - Todd, C.

AU - Williams, R.

AU - Reeve, J.

AU - Eastell, R.

AU - Woolf, A. D.

PY - 1997

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KW - Oral contraceptive pill

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KW - Vertebral osteoporosis

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