Influence of hyperprolactinemia induced by adenopituitary transplantation under the kidney capsule on the glutamic acid decarboxylase activity in various brain regions

F. Nicoletti, R. M. Di Giorgio, F. Patti, L. Rampello, D. F. Condorelli, M. Amico-Roxas, P. L. Canonico, U. Scapagnini

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Glutamic acid decarboxylase activity was assayed in rat substantia nigra, corpus striatum, medial basal hypothalamus and cerebellum under conditions of hyperprolactemia induced by transplantation of adenopituitary under the kidney capsule. The results indicate that hyperprolactinemia induces a slight increase in the glutamic acid decarboxylase activity of substantia nigra and medial basal hypothalamus and a more evident increase at striatal level. No change was observed in the cerebellum.

Original languageEnglish
Pages (from-to)153-157
Number of pages5
JournalArchives Internationales de Pharmacodynamie et de Therapie
Issue number1
Publication statusPublished - 1981


ASJC Scopus subject areas

  • Pharmacology

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