Influence of Inflow Cannula Length in Axial-flow Pumps on Neurologic Adverse Event Rate: Results From a Multi-center Analysis

Christof Schmid, Michael Jurmann, Dietrich Birnbaum, Tiziano Colombo, Volkmar Falk, Giuseppe Feltrin, Andrea Garatti, Michele Genoni, Gino Gerosa, Peter Göttel, Jan Gummert, Robert Halfmann, Dieter Hammel, Ewald Hennig, Friedrich Kaufmann, Marco Lanfranconi, Bart Meyns, Friedrich Mohr, Johannes Müller, Dimitar NikolovKestutis Rucinskas, Hans Heinrich Scheld, Franz Xaver Schmid, Michael Schneider, Vytautas Sirvydis, René Tandler, Ettore Vitali, Dirk Vlasselaers, Michael Weyand, Markus Wilhelm, Roland Hetzer

Research output: Contribution to journalArticle

Abstract

Background: The application of axial-flow pumps in patients with end-stage heart failure reveals a significantly reduced infectious complication rate as compared with rates observed with pulsatile devices. The remaining adverse event rate relates mainly to thromboembolic complications with neurologic consequences. We investigated the dependence of the neurologic adverse event rate on the length of the inflow cannula. Methods: A total of 216 consecutive patients with an axial-flow pump (INCOR; Berlin Heart GmbH, Berlin, Germany) were included in a retrospective multi-center analysis. In 138 patients, a short inflow cannula (24-mm tip length into the left ventricle), and in 78 patients a long inflow cannula (tip length 34 mm) was applied. Results: Patients with a long inflow cannula (LC) demonstrated a better survival rate than those with a short inflow cannula (SC) at the end of the observation period (LC, 63.4%; SC, 52.9%; p = 0.05). The thromboembolic adverse event rate was also significantly lower. Only 3 of the 78 patients (3.8%) with an LC had a thromboembolic adverse event (thromboembolic events per patient-year = 0.11) as compared with 32 (23.2%) of SC patients (thromboembolic events per patient-year = 0.50, p <0.001). Conclusions: Patients with a long inflow cannula had a better survival rate and a lower incidence of cerebrovascular adverse events than patients with a short inflow cannula.

Original languageEnglish
Pages (from-to)253-260
Number of pages8
JournalJournal of Heart and Lung Transplantation
Volume27
Issue number3
DOIs
Publication statusPublished - Mar 2008

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Nervous System
Berlin
Cannula
Survival Rate
Heart Ventricles
Germany
Heart Failure
Observation
Equipment and Supplies
Incidence

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Surgery
  • Transplantation

Cite this

Influence of Inflow Cannula Length in Axial-flow Pumps on Neurologic Adverse Event Rate : Results From a Multi-center Analysis. / Schmid, Christof; Jurmann, Michael; Birnbaum, Dietrich; Colombo, Tiziano; Falk, Volkmar; Feltrin, Giuseppe; Garatti, Andrea; Genoni, Michele; Gerosa, Gino; Göttel, Peter; Gummert, Jan; Halfmann, Robert; Hammel, Dieter; Hennig, Ewald; Kaufmann, Friedrich; Lanfranconi, Marco; Meyns, Bart; Mohr, Friedrich; Müller, Johannes; Nikolov, Dimitar; Rucinskas, Kestutis; Scheld, Hans Heinrich; Schmid, Franz Xaver; Schneider, Michael; Sirvydis, Vytautas; Tandler, René; Vitali, Ettore; Vlasselaers, Dirk; Weyand, Michael; Wilhelm, Markus; Hetzer, Roland.

In: Journal of Heart and Lung Transplantation, Vol. 27, No. 3, 03.2008, p. 253-260.

Research output: Contribution to journalArticle

Schmid, C, Jurmann, M, Birnbaum, D, Colombo, T, Falk, V, Feltrin, G, Garatti, A, Genoni, M, Gerosa, G, Göttel, P, Gummert, J, Halfmann, R, Hammel, D, Hennig, E, Kaufmann, F, Lanfranconi, M, Meyns, B, Mohr, F, Müller, J, Nikolov, D, Rucinskas, K, Scheld, HH, Schmid, FX, Schneider, M, Sirvydis, V, Tandler, R, Vitali, E, Vlasselaers, D, Weyand, M, Wilhelm, M & Hetzer, R 2008, 'Influence of Inflow Cannula Length in Axial-flow Pumps on Neurologic Adverse Event Rate: Results From a Multi-center Analysis', Journal of Heart and Lung Transplantation, vol. 27, no. 3, pp. 253-260. https://doi.org/10.1016/j.healun.2007.12.007
Schmid, Christof ; Jurmann, Michael ; Birnbaum, Dietrich ; Colombo, Tiziano ; Falk, Volkmar ; Feltrin, Giuseppe ; Garatti, Andrea ; Genoni, Michele ; Gerosa, Gino ; Göttel, Peter ; Gummert, Jan ; Halfmann, Robert ; Hammel, Dieter ; Hennig, Ewald ; Kaufmann, Friedrich ; Lanfranconi, Marco ; Meyns, Bart ; Mohr, Friedrich ; Müller, Johannes ; Nikolov, Dimitar ; Rucinskas, Kestutis ; Scheld, Hans Heinrich ; Schmid, Franz Xaver ; Schneider, Michael ; Sirvydis, Vytautas ; Tandler, René ; Vitali, Ettore ; Vlasselaers, Dirk ; Weyand, Michael ; Wilhelm, Markus ; Hetzer, Roland. / Influence of Inflow Cannula Length in Axial-flow Pumps on Neurologic Adverse Event Rate : Results From a Multi-center Analysis. In: Journal of Heart and Lung Transplantation. 2008 ; Vol. 27, No. 3. pp. 253-260.
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abstract = "Background: The application of axial-flow pumps in patients with end-stage heart failure reveals a significantly reduced infectious complication rate as compared with rates observed with pulsatile devices. The remaining adverse event rate relates mainly to thromboembolic complications with neurologic consequences. We investigated the dependence of the neurologic adverse event rate on the length of the inflow cannula. Methods: A total of 216 consecutive patients with an axial-flow pump (INCOR; Berlin Heart GmbH, Berlin, Germany) were included in a retrospective multi-center analysis. In 138 patients, a short inflow cannula (24-mm tip length into the left ventricle), and in 78 patients a long inflow cannula (tip length 34 mm) was applied. Results: Patients with a long inflow cannula (LC) demonstrated a better survival rate than those with a short inflow cannula (SC) at the end of the observation period (LC, 63.4{\%}; SC, 52.9{\%}; p = 0.05). The thromboembolic adverse event rate was also significantly lower. Only 3 of the 78 patients (3.8{\%}) with an LC had a thromboembolic adverse event (thromboembolic events per patient-year = 0.11) as compared with 32 (23.2{\%}) of SC patients (thromboembolic events per patient-year = 0.50, p <0.001). Conclusions: Patients with a long inflow cannula had a better survival rate and a lower incidence of cerebrovascular adverse events than patients with a short inflow cannula.",
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T1 - Influence of Inflow Cannula Length in Axial-flow Pumps on Neurologic Adverse Event Rate

T2 - Results From a Multi-center Analysis

AU - Schmid, Christof

AU - Jurmann, Michael

AU - Birnbaum, Dietrich

AU - Colombo, Tiziano

AU - Falk, Volkmar

AU - Feltrin, Giuseppe

AU - Garatti, Andrea

AU - Genoni, Michele

AU - Gerosa, Gino

AU - Göttel, Peter

AU - Gummert, Jan

AU - Halfmann, Robert

AU - Hammel, Dieter

AU - Hennig, Ewald

AU - Kaufmann, Friedrich

AU - Lanfranconi, Marco

AU - Meyns, Bart

AU - Mohr, Friedrich

AU - Müller, Johannes

AU - Nikolov, Dimitar

AU - Rucinskas, Kestutis

AU - Scheld, Hans Heinrich

AU - Schmid, Franz Xaver

AU - Schneider, Michael

AU - Sirvydis, Vytautas

AU - Tandler, René

AU - Vitali, Ettore

AU - Vlasselaers, Dirk

AU - Weyand, Michael

AU - Wilhelm, Markus

AU - Hetzer, Roland

PY - 2008/3

Y1 - 2008/3

N2 - Background: The application of axial-flow pumps in patients with end-stage heart failure reveals a significantly reduced infectious complication rate as compared with rates observed with pulsatile devices. The remaining adverse event rate relates mainly to thromboembolic complications with neurologic consequences. We investigated the dependence of the neurologic adverse event rate on the length of the inflow cannula. Methods: A total of 216 consecutive patients with an axial-flow pump (INCOR; Berlin Heart GmbH, Berlin, Germany) were included in a retrospective multi-center analysis. In 138 patients, a short inflow cannula (24-mm tip length into the left ventricle), and in 78 patients a long inflow cannula (tip length 34 mm) was applied. Results: Patients with a long inflow cannula (LC) demonstrated a better survival rate than those with a short inflow cannula (SC) at the end of the observation period (LC, 63.4%; SC, 52.9%; p = 0.05). The thromboembolic adverse event rate was also significantly lower. Only 3 of the 78 patients (3.8%) with an LC had a thromboembolic adverse event (thromboembolic events per patient-year = 0.11) as compared with 32 (23.2%) of SC patients (thromboembolic events per patient-year = 0.50, p <0.001). Conclusions: Patients with a long inflow cannula had a better survival rate and a lower incidence of cerebrovascular adverse events than patients with a short inflow cannula.

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