Influence of insulin on β-endorphin plasma levels in obese and normal weight subjects

A. Brunani, A. I. Pincelli, L. Pasqualinotto, A. Tibaldi, G. Baldi, M. Scacchi, L. M. Fatti, F. Cavagnini

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Objective: To establish the possible role of hyperinsulinemia in the elevation of plasma β-endorphin (β-EP) levels observed in obese patients after an oral glucose load. Design: Oral glucose tolerance test (OGTT) and euglycemic-hyperinsulinemic clamp. Subjects: Two groups of six (age: 22-39 y, BMI: 30-48 kg/m2) and eight obese men (age: 18-37 y, BMI: 35-45 kg/m2), respectively, and five normal weight healthy men (age: 22-30 y, BMI 22-23 kg/m2). Measurements: Glucose, insulin and β-EP levels at baseline and every 30 min until 180 min during the OGTT; glucose, insulin, C-peptide and β-EP concentrations at baseline and in steady state condition (i.e. during the last 30 min of insulin infusion) in the euglycemic-hyperinsulinemic clamp studies. Results: In the six obese patients undergoing the OGTT a significant elevation of β-EP plasma levels was observed between 60 and 90 min after glucose ingestion. In the clamp studies no significant differences in β-EP plasma levels, blood glucose and serum insulin were observed between obese and normal weight subjects both at baseline and at steady state. A markedly diminished insulin sensitivity along with a lower inhibition of C-peptide during insulin infusion was observed in obese patients compared to control subjects. Conclusion: A rise in serum insulin levels unaccompanied by a concomitant increase in blood glucose concentration is unable to elicit a β-EP response in obese patients.

Original languageEnglish
Pages (from-to)710-714
Number of pages5
JournalInternational Journal of Obesity
Volume20
Issue number8
Publication statusPublished - 1996

Fingerprint

Endorphins
endorphins
insulin
Insulin
Weights and Measures
Glucose Tolerance Test
Glucose
glucose
Glucose Clamp Technique
C-Peptide
blood serum
blood glucose
Blood Glucose
peptides
hyperinsulinemia
Hyperinsulinism
Serum
insulin resistance
Insulin Resistance
mouth

Keywords

  • β-endorphin
  • Euglycemic-hyperinsulinemic clamp
  • Obesity

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Public Health, Environmental and Occupational Health
  • Endocrinology
  • Food Science
  • Endocrinology, Diabetes and Metabolism

Cite this

Influence of insulin on β-endorphin plasma levels in obese and normal weight subjects. / Brunani, A.; Pincelli, A. I.; Pasqualinotto, L.; Tibaldi, A.; Baldi, G.; Scacchi, M.; Fatti, L. M.; Cavagnini, F.

In: International Journal of Obesity, Vol. 20, No. 8, 1996, p. 710-714.

Research output: Contribution to journalArticle

Brunani, A, Pincelli, AI, Pasqualinotto, L, Tibaldi, A, Baldi, G, Scacchi, M, Fatti, LM & Cavagnini, F 1996, 'Influence of insulin on β-endorphin plasma levels in obese and normal weight subjects', International Journal of Obesity, vol. 20, no. 8, pp. 710-714.
Brunani, A. ; Pincelli, A. I. ; Pasqualinotto, L. ; Tibaldi, A. ; Baldi, G. ; Scacchi, M. ; Fatti, L. M. ; Cavagnini, F. / Influence of insulin on β-endorphin plasma levels in obese and normal weight subjects. In: International Journal of Obesity. 1996 ; Vol. 20, No. 8. pp. 710-714.
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abstract = "Objective: To establish the possible role of hyperinsulinemia in the elevation of plasma β-endorphin (β-EP) levels observed in obese patients after an oral glucose load. Design: Oral glucose tolerance test (OGTT) and euglycemic-hyperinsulinemic clamp. Subjects: Two groups of six (age: 22-39 y, BMI: 30-48 kg/m2) and eight obese men (age: 18-37 y, BMI: 35-45 kg/m2), respectively, and five normal weight healthy men (age: 22-30 y, BMI 22-23 kg/m2). Measurements: Glucose, insulin and β-EP levels at baseline and every 30 min until 180 min during the OGTT; glucose, insulin, C-peptide and β-EP concentrations at baseline and in steady state condition (i.e. during the last 30 min of insulin infusion) in the euglycemic-hyperinsulinemic clamp studies. Results: In the six obese patients undergoing the OGTT a significant elevation of β-EP plasma levels was observed between 60 and 90 min after glucose ingestion. In the clamp studies no significant differences in β-EP plasma levels, blood glucose and serum insulin were observed between obese and normal weight subjects both at baseline and at steady state. A markedly diminished insulin sensitivity along with a lower inhibition of C-peptide during insulin infusion was observed in obese patients compared to control subjects. Conclusion: A rise in serum insulin levels unaccompanied by a concomitant increase in blood glucose concentration is unable to elicit a β-EP response in obese patients.",
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AU - Fatti, L. M.

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