Influence of intra-coronary enhancement on diagnostic accuracy with 64-slice CT coronary angiography

Filippo Cademartiri, Erica Maffei, Anselmo Alessandro Palumbo, Roberto Malagò, Ludovico La Grutta, W. Bob Meiijboom, Annachiara Aldrovandi, Michele Fusaro, Luigi Vignali, Alberto Menozzi, Valerio Brambilla, Paolo Coruzzi, Massimo Midiri, Miles A. Kirchin, Nico R A Mollet, Gabriel P. Krestin

Research output: Contribution to journalArticle


We assessed the effect of intra-coronary attenuation on diagnostic accuracy using 64-slice computed tomography coronary angiography (CT-CA). We enrolled 170 patients with suspected coronary artery disease who underwent conventional coronary angiography (CA) and 64-slice CT-CA (100 ml of Iomeprol 400 mg I/ml at 4 ml/s). The study population was divided into two groups (85 patients each based on median attenuation of 326 HU) based on mean arterial attenuation; group 1 with low attenuation and group 2 with high attenuation. Diagnostic accuracy for the detection of significant coronary artery stenosis was determined for both groups using CA as reference standard. Overall, 163 significant stenoses were detected in 1,030 assessable coronary artery segments in group 1 compared with 160 significant stenoses in 1,020 assessable segments in group 2. The average intra-coronary attenuation was significantly (P

Original languageEnglish
Pages (from-to)576-583
Number of pages8
JournalEuropean Radiology
Issue number3
Publication statusPublished - Mar 2008



  • Coronary angiography
  • Coronary artery disease
  • Diagnostic accuracy
  • Iodine concentration
  • Multislice computed tomography

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Cademartiri, F., Maffei, E., Palumbo, A. A., Malagò, R., La Grutta, L., Meiijboom, W. B., Aldrovandi, A., Fusaro, M., Vignali, L., Menozzi, A., Brambilla, V., Coruzzi, P., Midiri, M., Kirchin, M. A., Mollet, N. R. A., & Krestin, G. P. (2008). Influence of intra-coronary enhancement on diagnostic accuracy with 64-slice CT coronary angiography. European Radiology, 18(3), 576-583.