Influence of intraoperative capsule rupture on outcomes in stage i epithelial ovarian cancer

Jamie N. Bakkum-Gamez, Debra L. Richardson, Leigh G. Seamon, Giovanni D. Aletti, Cecelia A. Powless, Gary L. Keeney, David M. O'Malley, William A. Cliby

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Abstract

Objective: To evaluate the effect of tumor capsule rupture on disease prognosis in stage I epithelial ovarian cancer. Methods: All patients with International Federation of Gynecology and Obstetrics stage I epithelial ovarian cancer operated on at the Mayo Clinic and The Ohio State University between January 1991 and December 2007 were identified. Relevant tumor characteristics, procedures performed, adjuvant therapies, and follow-up were recorded and analyzed. Inclusion criteria included comprehensive staging. Cox proportional hazards, Kaplan-Meier estimation, log rank test, and χ test were used for statistical analyses. Results: There were 161 cases that met inclusion criteria. Seventy-four (46%) patients had intact capsules without positive cytology or surface involvement; 61 (38%) had capsule rupture; 33 (20%) had positive cytology; and 22 (14%) had surface involvement. Overall, 22 of 161 (14%) patients recurred and 12 of 161 (7%) patients died of their disease. In univariable analysis, both intraoperative capsule rupture and positive cytologic washings portended worse disease-free survival (hazard ratio [HR] 3.6, 95% confidence interval [CI] 1.5-8.9; P=.004 and HR 5.2, 95% CI 2.1-12.3; P

Original languageEnglish
Pages (from-to)11-17
Number of pages7
JournalObstetrics and Gynecology
Volume113
Issue number1
DOIs
Publication statusPublished - Jan 2009

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ASJC Scopus subject areas

  • Obstetrics and Gynaecology

Cite this

Bakkum-Gamez, J. N., Richardson, D. L., Seamon, L. G., Aletti, G. D., Powless, C. A., Keeney, G. L., O'Malley, D. M., & Cliby, W. A. (2009). Influence of intraoperative capsule rupture on outcomes in stage i epithelial ovarian cancer. Obstetrics and Gynecology, 113(1), 11-17. https://doi.org/10.1097/AOG.0b013e3181917a0c