Influence of L-dopa on ERD in asymmetric idiopathic Parkinson's disease

G. Magnani, M. Cursi, L. Leocani, M. A. Volonté, N. Canal, L. Moiola, G. Comi

Research output: Contribution to journalArticle

Abstract

Event-related desynchronization (ERD) of the mu rhythm preceding self-paced movement is a useful tool for investigating the activation of cortical areas involved in motor preparation. ERD is delayed in patients with akinetic idiopathic Parkinson's disease (IPD), especially for movement of the affected side in hemiparkinson patients, and is improved by chronic L-dopa treatment. We evaluated the effect of the acute administration of L-dopa on ERD in patients affected by asymmetric IPD. Mu ERD to self-paced finger flexion was evaluated in 14 patients with an asymmetric, rigid-akinetic form of IPD with predominance on the left side, 30 min before and after oral administration of 200 mg of dispersible L-dopa plus 50 mg of benserazide. Data were compared to 10 age-matched normal subjects. In IPD before L-dopa administration, contralateral sensorimotor ERD occurred closer to movement than in the control group for movement of either side (P

Original languageEnglish
JournalNeurological Sciences
Volume21
Issue number4 SUPPL.
Publication statusPublished - 2000

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Levodopa
Parkinson Disease
Benserazide
Fingers
Oral Administration
Control Groups
Therapeutics

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology

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Influence of L-dopa on ERD in asymmetric idiopathic Parkinson's disease. / Magnani, G.; Cursi, M.; Leocani, L.; Volonté, M. A.; Canal, N.; Moiola, L.; Comi, G.

In: Neurological Sciences, Vol. 21, No. 4 SUPPL., 2000.

Research output: Contribution to journalArticle

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AU - Volonté, M. A.

AU - Canal, N.

AU - Moiola, L.

AU - Comi, G.

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