Influence of left ventricular asynchrony on filling in coronary artery disease

Pasquale Perrone-Filardi, Sandro Betocchi, Gabriella Giustino, Federico Piscione, Ciro Indolfi, Marco Salvatore, Massimo Chiariello

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To evaluate whether the extent of left ventricular (LV) asynchrony plays a role in the impairment of LV rapid filling in patients with coronary artery disease (CAD), 48 patients underwent both radionuclide angiography and cardiac catheterization. Patients were divided into group I (n = 33), with normal LV kinesis or only mild hypokinesia, and group II (n = 15), with LV dyskinesia or akinesia. Radionuclide ejection fraction was higher in group I than in group II (62 ± 12 vs 44 ± 20%; p <0.001). Peak filling rate was significantly lower in group II (1.9 ± 0.8 vs 2.6 ± 0.9 end-diastolic counts/s; p <0.01). Time to end-systole coefficient of variation, an index of the extent of LV asynchrony, was significantly higher in group II than in group I (43 ± 10 vs 35 ± 6; p <0.0002). In group I, a highly significant inverse relation was found between this index of asynchrony and peak filling rate (r = 0.71; p <0.0001). This correlation was found even when time to end-systole coefficient of variation was normalized to the RR interval (r = 0.49; p <0.01) and when peak filling rate was expressed in stroke counts (r = 0.57; p <0.001). The correlation between peak filling rate and index of asynchrony was maintained up to an end-systole coefficient of variation value of approximately 35. In group II patients (most with an asynchrony value ≥35) no relation was found between time to end-systole coefficient of variation and peak filling rate.

Original languageEnglish
Pages (from-to)523-527
Number of pages5
JournalThe American Journal of Cardiology
Issue number9
Publication statusPublished - Sep 15 1988

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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