Influence of macular choroidal thickness on visual function in highly myopic eyes

Mariacristina Parravano, Francesco Oddone, Paola Giorno, Andrea Cacciamani, Rosa Abbate, Giulia Caminiti, Enrico Peiretti, Monica Varano

Research output: Contribution to journalArticle

Abstract

Purpose: To explore the retinal and choroidal thicknesses (RT, CT), as measured using enhanced depth imaging (EDI) optical coherence tomography (OCT, Spectralis) in highly myopic eyes and its relationship with visual function. Materials and Methods: Prospective, case-control, noninterventional clinical study. CT was measured by EDI-OCT in highly myopic eyes (≥6 dpt) without any macular diseases and age-matched control eyes. A complete ophthalmological examination, visual acuity assessment and MP1 microperimetry were obtained. Results: 38 myopic (15 M/23 F, mean age 51 ± 8.9 years) and 21 control eyes (5 M/16 F, mean age 50 ± 5.4 years) were included. The myopic mean refractive error was -13.3 ± 4.9 dpt and axial length 29.2 ± 2.2 mm. The mean best-corrected visual acuity (BCVA) was lower in highly myopic than in control eyes (77.3 ± 9.25 vs. 84.8 ± 0.6 letters, p = 0.0001, respectively) as was the mean retinal sensitivity (MRS; 16.32 ± 2.6 vs. 19.9 ± 0.2 dB, p <0.0001). While RT was similar between groups (291.5 ± 24.2 vs. 283.6 ± 13.9 μm, p = 0.06, respectively), subfoveal CT was thinner in highly myopic compared to control eyes (114.3 ± 78.5 vs. 272.6 ± 110.2 μm, p <0.0001). A significant relationship was found between subfoveal CT and MRS (R2 = 0.22; p = 0.003) and BCVA (R2 = 0.13; p = 0.027). Conclusions: Macular function is reduced in highly myopic eyes without any visible macular diseases compared to controls, and a significant proportion of the macular function variability seems to be related to a reduced CT.

Original languageEnglish
Pages (from-to)97-101
Number of pages5
JournalOphthalmic Research
Volume52
Issue number2
DOIs
Publication statusPublished - Apr 14 2014

Keywords

  • Choroid
  • Choroidal thickness
  • Microperimetry
  • Myopia
  • Optical coherence tomography
  • Retinal sensitivity

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience
  • Medicine(all)

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