Influence of meal ingestion on insulin profiles following intraperitoneal delivery

Marina Scavini, Angela I. Pincelli, Carla Cruciani, Beatrice Giberti, Emanuela Orsi, Gabriella Galimberti, Giovanna Petrella, Marco Cristallo, Guido Pozza, Piero Micossi

Research output: Contribution to journalArticlepeer-review

Abstract

This study evaluated the effect of meal ingestion on intraperitoneal insulin absorption in type I diabetic patients with an implanted pump for long-term intraperitoneal insulin delivery. On four separate occasions, patients (n = 7) were administered 15 IU insulin as a 20-minute square-wave infusion using their implanted device; hypoglycemia was prevented by intravenous infusion of 10% dextrose at a variable rate. Two studies were performed during fasting conditions (n = 2 fasting tests) and two studies after the administration of an 800-kcal standard meal (n = 2 postprandial tests). An insulin peak of 630 ± 545.4 pmol/L (mean ± SD) in fasting tests and 696 ± 420.5 pmol/L in postprandial tests was reached in the peripheral circulation after 45 ± 11.7 and 45 ± 14.7 minutes, respectively, with no significant difference between the two experimental conditions. Areas under the insulin curves were not significantly different in fasting and postprandial tests (51,500 ± 34,278 v 50,916 ± 20,558 pmol/L · min-1, respectively; NS). In type I diabetic patients receiving long-term intraperitoneal insulin therapy, the increase in splanchnic blood flow following ingestion of a standard meal does not accelerate the appearance of insulin in the peripheral circulation.

Original languageEnglish
Pages (from-to)1013-1016
Number of pages4
JournalMetabolism
Volume42
Issue number8
DOIs
Publication statusPublished - 1993

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

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