Influence of Methylprednisolone on Plasma Homocysteine Levels in Cadaveric Renal Transplant Recipients

C. Libetta, V. Sepe, M. Zucchi, P. Pisacco, V. Portalupi, G. Adamo, G. Soccio, A. Dal Canton

Research output: Contribution to journalArticle

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Abstract

The aim of the present study was to investigate plasma homocysteine levels in renal transplant recipients in the course of steroid-based or steroid-free immunosuppression. Data from 32 patients were retrospectively analyzed according to the steroid immunosuppressive regimen. The 20 recipients on methylprednisolone (MP) plus cyclosporine (CyA) or tacrolimus (TRL) (n = 20) showed similar creatinine levels when compared with those on calcineurin inhibitors plus mycophenolate mofetil (MMF; n = 12), (1.6 ± 1.5 vs 1.6 ± 0.4 mg/dL; P = NS) but significantly higher total plasma homocysteine (tHcy) levels (28.5 ± 12.5 vs 16.3 ± 5.5 μmol/L; P <.05). No differences of tHcy levels have been observed when patients were analyzed according to CyA- or TRL-based immunosuppression regardless of MP or MMF associations. Our data suggest that recipients, particularly those on steroid-based immunosuppression, should receive homocysteine-lowering treatment early after transplantation.

Original languageEnglish
Pages (from-to)2893-2894
Number of pages2
JournalTransplantation Proceedings
Volume38
Issue number9
DOIs
Publication statusPublished - Nov 2006

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Methylprednisolone
Homocysteine
Steroids
Immunosuppression
Kidney
Tacrolimus
Mycophenolic Acid
Immunosuppressive Agents
Cyclosporine
Creatinine
Transplantation
Transplant Recipients
Therapeutics

ASJC Scopus subject areas

  • Surgery
  • Transplantation

Cite this

Influence of Methylprednisolone on Plasma Homocysteine Levels in Cadaveric Renal Transplant Recipients. / Libetta, C.; Sepe, V.; Zucchi, M.; Pisacco, P.; Portalupi, V.; Adamo, G.; Soccio, G.; Dal Canton, A.

In: Transplantation Proceedings, Vol. 38, No. 9, 11.2006, p. 2893-2894.

Research output: Contribution to journalArticle

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AU - Adamo, G.

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