Influence of Methylprednisolone on Plasma Homocysteine Levels in Cadaveric Renal Transplant Recipients

C. Libetta, V. Sepe, M. Zucchi, P. Pisacco, V. Portalupi, G. Adamo, G. Soccio, A. Dal Canton

Research output: Contribution to journalArticle

Abstract

The aim of the present study was to investigate plasma homocysteine levels in renal transplant recipients in the course of steroid-based or steroid-free immunosuppression. Data from 32 patients were retrospectively analyzed according to the steroid immunosuppressive regimen. The 20 recipients on methylprednisolone (MP) plus cyclosporine (CyA) or tacrolimus (TRL) (n = 20) showed similar creatinine levels when compared with those on calcineurin inhibitors plus mycophenolate mofetil (MMF; n = 12), (1.6 ± 1.5 vs 1.6 ± 0.4 mg/dL; P = NS) but significantly higher total plasma homocysteine (tHcy) levels (28.5 ± 12.5 vs 16.3 ± 5.5 μmol/L; P <.05). No differences of tHcy levels have been observed when patients were analyzed according to CyA- or TRL-based immunosuppression regardless of MP or MMF associations. Our data suggest that recipients, particularly those on steroid-based immunosuppression, should receive homocysteine-lowering treatment early after transplantation.

Original languageEnglish
Pages (from-to)2893-2894
Number of pages2
JournalTransplantation Proceedings
Volume38
Issue number9
DOIs
Publication statusPublished - Nov 2006

ASJC Scopus subject areas

  • Surgery
  • Transplantation

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