Influence of nimodipine on cerebral blood flow in human cerebral ischaemia

C. Pozzilli, V. Di Piero, P. Pantano, M. Rasura, G. L. Lenzi

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Abstract

Cerebral blood flow (CBF) was measured by xenon-133 inhalation and single photon emission computerized tomography (SPECT) in 7 patients with acute cerebral ischaemia prior to and 30 min after intravenous infusion of nimodipine (1 mg). Neurological examination, CT and CBF study were performed no later than 6 h after the onset of symptoms. Regional perfusion abnormalities were seen in all patients when the CT scan was still normal. Follow-up CT revealed low-density areas roughly corresponding to the core of the perfusion defect. Nimodipine infusion significantly decreased the mean arterial blood pressure (P2 and clinical symptoms remained unchanged. A significant CBF improvement (P

Original languageEnglish
Pages (from-to)199-202
Number of pages4
JournalJournal of Neurology
Volume236
Issue number4
DOIs
Publication statusPublished - May 1989

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Keywords

  • Cerebral blood flow
  • Cerebral ischaemia
  • Nimodipine

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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