Influence of normalization techniques upon two-dimensional Doppler-derived peak filling rate: Comparison with radionuclide angiography

D. Bonaduce, G. Morgano, R. Breglio, G. Conforti, M. Petretta, S. Betocchi, M. Salvatore, M. Chiariello

Research output: Contribution to journalArticlepeer-review

Abstract

In this study we evaluated if two-dimensional Doppler (2DD)-derived peak filling rate (PFR) normalized to stroke volume (SV) could provide a useful index of diastolic function that can be compared to PFR obtained with radionuclide angiography (RNA). Forty-five patients, 22 with clinical evidence of healed myocardial infarction (MI) and 23 of primary hypertension underwent 2DD and RNA study within 24 h. 2DD- and RNA-derived PFR were normalized to end-diastolic volume (PFR-EDV) and to SV (PFR-SV): PFR determined by 2DD correlated with RNA in the total study population (r = 0.45; p <0.01), in MI (r = 0.51; p <0.01) and in hypertensive (H) patients (r = 0.43; p <0.05) when both were normalized to SV; however, when normalized to end-diastolic volume, 2DD-derived PFR also correlated with RNA in the total study population (r = 0.36; p <0.05) and in H patients (r = 0.48; p <0.05) but not in MI patients (r = 0.37; NS). Furthermore, PFR-SV and PFR-EDV measured by RNA closely correlated in the total study population (r = 0.81; p <0.001), in MI (r = 0.86; p <0.001), and in H patients (r = 0.86; p <0.001), while, when assessed by 2DD, the r values of the correlations between the same parameters in the total study population (r = 0.44; p <0.01), in MI (r = 0.47; p <0.05) and in H patients (r = 0.43; p <0.05) were lower. Thus, 2DD-derived PFR normalized to SV more than to EDV might be useful in assessing left ventricular diastolic filling abnormalities in cardiac patients, in particular in those with healed MI.

Original languageEnglish
Pages (from-to)74-79
Number of pages6
JournalAmerican Journal of Noninvasive Cardiology
Volume3
Issue number2-3
Publication statusPublished - 1989

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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