Abstract
In this study we evaluated if two-dimensional Doppler (2DD)-derived peak filling rate (PFR) normalized to stroke volume (SV) could provide a useful index of diastolic function that can be compared to PFR obtained with radionuclide angiography (RNA). Forty-five patients, 22 with clinical evidence of healed myocardial infarction (MI) and 23 of primary hypertension underwent 2DD and RNA study within 24 h. 2DD- and RNA-derived PFR were normalized to end-diastolic volume (PFR-EDV) and to SV (PFR-SV): PFR determined by 2DD correlated with RNA in the total study population (r = 0.45; p <0.01), in MI (r = 0.51; p <0.01) and in hypertensive (H) patients (r = 0.43; p <0.05) when both were normalized to SV; however, when normalized to end-diastolic volume, 2DD-derived PFR also correlated with RNA in the total study population (r = 0.36; p <0.05) and in H patients (r = 0.48; p <0.05) but not in MI patients (r = 0.37; NS). Furthermore, PFR-SV and PFR-EDV measured by RNA closely correlated in the total study population (r = 0.81; p <0.001), in MI (r = 0.86; p <0.001), and in H patients (r = 0.86; p <0.001), while, when assessed by 2DD, the r values of the correlations between the same parameters in the total study population (r = 0.44; p <0.01), in MI (r = 0.47; p <0.05) and in H patients (r = 0.43; p <0.05) were lower. Thus, 2DD-derived PFR normalized to SV more than to EDV might be useful in assessing left ventricular diastolic filling abnormalities in cardiac patients, in particular in those with healed MI.
| Original language | English |
|---|---|
| Pages (from-to) | 74-79 |
| Number of pages | 6 |
| Journal | American Journal of Noninvasive Cardiology |
| Volume | 3 |
| Issue number | 2-3 |
| Publication status | Published - 1989 |
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ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
Cite this
Influence of normalization techniques upon two-dimensional Doppler-derived peak filling rate : Comparison with radionuclide angiography. / Bonaduce, D.; Morgano, G.; Breglio, R.; Conforti, G.; Petretta, M.; Betocchi, S.; Salvatore, M.; Chiariello, M.
In: American Journal of Noninvasive Cardiology, Vol. 3, No. 2-3, 1989, p. 74-79.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Influence of normalization techniques upon two-dimensional Doppler-derived peak filling rate
T2 - Comparison with radionuclide angiography
AU - Bonaduce, D.
AU - Morgano, G.
AU - Breglio, R.
AU - Conforti, G.
AU - Petretta, M.
AU - Betocchi, S.
AU - Salvatore, M.
AU - Chiariello, M.
PY - 1989
Y1 - 1989
N2 - In this study we evaluated if two-dimensional Doppler (2DD)-derived peak filling rate (PFR) normalized to stroke volume (SV) could provide a useful index of diastolic function that can be compared to PFR obtained with radionuclide angiography (RNA). Forty-five patients, 22 with clinical evidence of healed myocardial infarction (MI) and 23 of primary hypertension underwent 2DD and RNA study within 24 h. 2DD- and RNA-derived PFR were normalized to end-diastolic volume (PFR-EDV) and to SV (PFR-SV): PFR determined by 2DD correlated with RNA in the total study population (r = 0.45; p <0.01), in MI (r = 0.51; p <0.01) and in hypertensive (H) patients (r = 0.43; p <0.05) when both were normalized to SV; however, when normalized to end-diastolic volume, 2DD-derived PFR also correlated with RNA in the total study population (r = 0.36; p <0.05) and in H patients (r = 0.48; p <0.05) but not in MI patients (r = 0.37; NS). Furthermore, PFR-SV and PFR-EDV measured by RNA closely correlated in the total study population (r = 0.81; p <0.001), in MI (r = 0.86; p <0.001), and in H patients (r = 0.86; p <0.001), while, when assessed by 2DD, the r values of the correlations between the same parameters in the total study population (r = 0.44; p <0.01), in MI (r = 0.47; p <0.05) and in H patients (r = 0.43; p <0.05) were lower. Thus, 2DD-derived PFR normalized to SV more than to EDV might be useful in assessing left ventricular diastolic filling abnormalities in cardiac patients, in particular in those with healed MI.
AB - In this study we evaluated if two-dimensional Doppler (2DD)-derived peak filling rate (PFR) normalized to stroke volume (SV) could provide a useful index of diastolic function that can be compared to PFR obtained with radionuclide angiography (RNA). Forty-five patients, 22 with clinical evidence of healed myocardial infarction (MI) and 23 of primary hypertension underwent 2DD and RNA study within 24 h. 2DD- and RNA-derived PFR were normalized to end-diastolic volume (PFR-EDV) and to SV (PFR-SV): PFR determined by 2DD correlated with RNA in the total study population (r = 0.45; p <0.01), in MI (r = 0.51; p <0.01) and in hypertensive (H) patients (r = 0.43; p <0.05) when both were normalized to SV; however, when normalized to end-diastolic volume, 2DD-derived PFR also correlated with RNA in the total study population (r = 0.36; p <0.05) and in H patients (r = 0.48; p <0.05) but not in MI patients (r = 0.37; NS). Furthermore, PFR-SV and PFR-EDV measured by RNA closely correlated in the total study population (r = 0.81; p <0.001), in MI (r = 0.86; p <0.001), and in H patients (r = 0.86; p <0.001), while, when assessed by 2DD, the r values of the correlations between the same parameters in the total study population (r = 0.44; p <0.01), in MI (r = 0.47; p <0.05) and in H patients (r = 0.43; p <0.05) were lower. Thus, 2DD-derived PFR normalized to SV more than to EDV might be useful in assessing left ventricular diastolic filling abnormalities in cardiac patients, in particular in those with healed MI.
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M3 - Article
VL - 3
SP - 74
EP - 79
JO - American Journal of Noninvasive Cardiology
JF - American Journal of Noninvasive Cardiology
SN - 0258-4425
IS - 2-3
ER -