Influence of opioid system on behavioral sensitization induced by cocaine in the rat

M. Sala, D. Braida, M. Colombo, F. Terzi, M. P. Leone, E. Gori

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Abstract

In rats, repeated daily ip administrations of a low dose (10 mg/kg) of cocaine HCl (COC) produced enhanced locomotor activity; a higher dose (50 mg/kg) led to seizures (pharmacological kindling). Daily pretreatment with naltrexone (NTX) (2 mg/kg/sc), injected 15 min prior to COC, completely antagonized COC-induced motor and convulsant activity, except on the first day when a potentiation of seizures was observed. Using the same treatment schedule, COC 50 mg/kg failed to induce sensitization to the well known local anesthetic properties evaluated through the loss of abdominal tone; this effect was not reversed by NTX pretreatment. These findings provide further evidence of the modulatory role of the opiate system on cocaine sensitization.

Original languageEnglish
JournalRegulatory Peptides
Volume53
Issue numberSUPPL. 1
DOIs
Publication statusPublished - Feb 21 1994

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ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology
  • Physiology
  • Neuroscience(all)

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