Influence of opioid system on behavioral sensitization induced by cocaine in the rat

M. Sala; D. Braida; M. Colombo; F. Terzi; M. P. Leone; E. Gori

doi:10.1016/0167-0115(94)90309-3

Influence of opioid system on behavioral sensitization induced by cocaine in the rat

M. Sala, D. Braida, M. Colombo, F. Terzi, M. P. Leone, E. Gori

Fondazione Don Carlo Gnocchi Onlus

Research output: Contribution to journal › Article

Abstract

In rats, repeated daily ip administrations of a low dose (10 mg/kg) of cocaine HCl (COC) produced enhanced locomotor activity; a higher dose (50 mg/kg) led to seizures (pharmacological kindling). Daily pretreatment with naltrexone (NTX) (2 mg/kg/sc), injected 15 min prior to COC, completely antagonized COC-induced motor and convulsant activity, except on the first day when a potentiation of seizures was observed. Using the same treatment schedule, COC 50 mg/kg failed to induce sensitization to the well known local anesthetic properties evaluated through the loss of abdominal tone; this effect was not reversed by NTX pretreatment. These findings provide further evidence of the modulatory role of the opiate system on cocaine sensitization.

Original language	English
Journal	Regulatory Peptides
Volume	53
Issue number	SUPPL. 1
DOIs	https://doi.org/10.1016/0167-0115(94)90309-3
Publication status	Published - Feb 21 1994

Fingerprint

ASJC Scopus subject areas

Biochemistry
Endocrinology
Physiology
Neuroscience(all)

Cite this

Sala, M., Braida, D., Colombo, M., Terzi, F., Leone, M. P., & Gori, E. (1994). Influence of opioid system on behavioral sensitization induced by cocaine in the rat. Regulatory Peptides, 53(SUPPL. 1). https://doi.org/10.1016/0167-0115(94)90309-3

@article{2a5c1d7d67734b50b93af0dc4ea0b359,

title = "Influence of opioid system on behavioral sensitization induced by cocaine in the rat",

abstract = "In rats, repeated daily ip administrations of a low dose (10 mg/kg) of cocaine HCl (COC) produced enhanced locomotor activity; a higher dose (50 mg/kg) led to seizures (pharmacological kindling). Daily pretreatment with naltrexone (NTX) (2 mg/kg/sc), injected 15 min prior to COC, completely antagonized COC-induced motor and convulsant activity, except on the first day when a potentiation of seizures was observed. Using the same treatment schedule, COC 50 mg/kg failed to induce sensitization to the well known local anesthetic properties evaluated through the loss of abdominal tone; this effect was not reversed by NTX pretreatment. These findings provide further evidence of the modulatory role of the opiate system on cocaine sensitization.",

author = "M. Sala and D. Braida and M. Colombo and F. Terzi and Leone, {M. P.} and E. Gori",

year = "1994",

month = feb

day = "21",

doi = "10.1016/0167-0115(94)90309-3",

language = "English",

volume = "53",

journal = "Regulatory Peptides",

issn = "0167-0115",

publisher = "Elsevier",

number = "SUPPL. 1",

}

TY - JOUR

T1 - Influence of opioid system on behavioral sensitization induced by cocaine in the rat

AU - Sala, M.

AU - Braida, D.

AU - Colombo, M.

AU - Terzi, F.

AU - Leone, M. P.

AU - Gori, E.

PY - 1994/2/21

Y1 - 1994/2/21

N2 - In rats, repeated daily ip administrations of a low dose (10 mg/kg) of cocaine HCl (COC) produced enhanced locomotor activity; a higher dose (50 mg/kg) led to seizures (pharmacological kindling). Daily pretreatment with naltrexone (NTX) (2 mg/kg/sc), injected 15 min prior to COC, completely antagonized COC-induced motor and convulsant activity, except on the first day when a potentiation of seizures was observed. Using the same treatment schedule, COC 50 mg/kg failed to induce sensitization to the well known local anesthetic properties evaluated through the loss of abdominal tone; this effect was not reversed by NTX pretreatment. These findings provide further evidence of the modulatory role of the opiate system on cocaine sensitization.

AB - In rats, repeated daily ip administrations of a low dose (10 mg/kg) of cocaine HCl (COC) produced enhanced locomotor activity; a higher dose (50 mg/kg) led to seizures (pharmacological kindling). Daily pretreatment with naltrexone (NTX) (2 mg/kg/sc), injected 15 min prior to COC, completely antagonized COC-induced motor and convulsant activity, except on the first day when a potentiation of seizures was observed. Using the same treatment schedule, COC 50 mg/kg failed to induce sensitization to the well known local anesthetic properties evaluated through the loss of abdominal tone; this effect was not reversed by NTX pretreatment. These findings provide further evidence of the modulatory role of the opiate system on cocaine sensitization.

UR - http://www.scopus.com/inward/record.url?scp=0028258387&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028258387&partnerID=8YFLogxK

U2 - 10.1016/0167-0115(94)90309-3

DO - 10.1016/0167-0115(94)90309-3

M3 - Article

AN - SCOPUS:0028258387

VL - 53

JO - Regulatory Peptides

JF - Regulatory Peptides

SN - 0167-0115

IS - SUPPL. 1

ER -

Access to Document

10.1016/0167-0115(94)90309-3