Influence of perioperative transfusion therapy on the recurrence potential of locally advanced laryngeal carcinoma

G. Bongioannini, M. Vercellino, M. G. Rugiu, A. Ferreri, G. Succo, G. Cortesina

Research output: Contribution to journalArticlepeer-review

Abstract

The present study was undertaken to determinate whether immunosuppression, induced by perioperative allogenic whole-blood transfusions (AWBTs), adversely affects prognosis after total resection of laryngeal cancer by promoting the appearance of recurrences. We studied 62 patients, aged 37-82 years with TNM stage III and IV (UICC, 1987) laryngeal cancer treated between 1977 and 1983. AWBTs were administered to 30/62 patients perioperatively. All patients were followed up for 4 years. After 4 years we found the following disease-free survival indexes: transfused, 12/30 (40%); nontransfused, 22/32 (70%; p <0.05). On the basis of these dates, we conclude that AWBTs exert a significant influence on early recurrence and on survival in patients with laryngeal cancer.

Original languageEnglish
Pages (from-to)260-264
Number of pages5
JournalORL
Volume52
Issue number4
Publication statusPublished - 1990

Keywords

  • immunodepression
  • laryngeal cancer
  • transfusions

ASJC Scopus subject areas

  • Otorhinolaryngology

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