Influence of polyethylene terephthalate on the release of growth factors by human endothelial cells

Elisabetta Cenni, Elisabetta Verri, Donatella Granchi, Simonetta Gamberini, Alessandra Corradini, Alessandro Di Leo, Lucio Montanaro, Arturo Pizzoferrato

Research output: Contribution to journalArticle

Abstract

The influence of polyethylene terephthalate (PET) on the release of platelet derived growth factor AB (PDGF-AB) and basic fibroblast growth factor (bFGF) by in vitro cultured human endothelial cells was assessed by enzyme immunoassay. No significant differences were observed in the production of PDGF-AB with respect to the negative control cultures. A significant increase was observed in the production of bFGF after 48 and 72 h with respect to the negative control cultures. It can be concluded that PET may induce an increase in the production of basic FGF in endothelial cells.

Original languageEnglish
Pages (from-to)891-900
Number of pages10
JournalJournal of Biomaterials Science, Polymer Edition
Volume10
Issue number9
Publication statusPublished - 1999

Keywords

  • Endothelial cell
  • Fibroblast growth factor
  • Platelet derived growth factor
  • Polyethylene terephthalate

ASJC Scopus subject areas

  • Biophysics

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  • Cite this

    Cenni, E., Verri, E., Granchi, D., Gamberini, S., Corradini, A., Di Leo, A., Montanaro, L., & Pizzoferrato, A. (1999). Influence of polyethylene terephthalate on the release of growth factors by human endothelial cells. Journal of Biomaterials Science, Polymer Edition, 10(9), 891-900.